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© 2005 Oxford University Press
ARTICLE |
Body Mass Index and Risk of Malignant Lymphoma in Scandinavian Men and Women
Affiliations of authors: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (ETC, KES, HOA); Department of Epidemiology Research, Danish Epidemiology Science Center, Statens Serum Institut, Copenhagen, Denmark (HH, MM); Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden (MÅ); Department of Pathology and Cytology, Karolinska University Hospital, Stockholm Sweden (ET); Department of Haematology, Herlev Amtssygehus, University of Copenhagen, Herlev, Denmark (HEJ); Department of Oncology, Radiology and Clinical Immunology, University of Uppsala, Uppsala, Sweden, and Department of Oncology and Pathology, Karolinska University Hospital, Stockholm, Sweden (BG)
Correspondence to: Ellen Chang, ScD, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden (e-mail: ellen.chang{at}meb.ki.se).
Background: The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case–control study. Methods: Telephone interviews were conducted with 3055 case patients with non-Hodgkin lymphoma and 618 case patients with Hodgkin lymphoma diagnosed between October 1, 1999, and August 30, 2002, and 3187 population-based control subjects. The interviews assessed current height, normal adult weight, and other possible risk factors. Multivariable odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for risk of lymphoma were estimated by unconditional logistic regression. All statistical tests were two-sided. Results: BMI was not associated with risk of overall non-Hodgkin lymphoma or of Hodgkin lymphoma (for example, comparing the highly obese group [BMI 
35.0 kg/m2] with the normal-weight group [BMI = 18.5–24.9 kg/m2], OR for risk of non-Hodgkin lymphoma = 0.9, 95% CI = 0.6 to 1.3; Ptrend across all categories of BMI = .27). BMI was also not associated with risk of any non-Hodgkin lymphoma subtype evaluated, although there was some evidence of a positive association with risk of diffuse large B-cell lymphoma (for example, comparing the highly obese group with the normal-weight group, OR for diffuse large B-cell lymphoma = 1.5, 95% CI = 0.9 to 2.4; Ptrend =.05). Conclusions: Excess weight does not appear to be associated with an increased risk of malignant lymphoma in general, or with a risk of most major lymphoma subtypes. Hence, the growing incidence of obesity is unlikely to be an important contributor to the increasing incidence of non-Hodgkin lymphoma worldwide.
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Correspondence about this Article
- Re: Body Mass Index and Risk of Malignant Lymphoma in Scandinavian Men and Women
- Cristina Bosetti, Luigino Dal Maso, Eva Negri, Renato Talamini, Maurizio Montella, Silvia Franceschi, and Carlo La Vecchia
J Natl Cancer Inst 2005 97: 860-861.[Extract] [Full Text] [PDF]
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