Genistein Modulates Immune Responses and Increases Host Resistance to B16F10 Tumor in Adult Female B6C3F1 Mice1,2
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Key words:
genistein
cytotoxic T cell activity
natural killer cell activity
antibody forming cell responses
B16F10 tumor model
Abbreviations:
AFC
antibody-forming cells
CTL
cytotoxic T lymphocyte
E-MEM
Eagle's minimal essential medium
FITC
fluorescein isothiocyanate
GEN
genistein
HBSS
Hank's balanced salt solution
IFN
interferon
Ig
immunoglobulin
IL
interleukin
iv
intravenously
LPS
lipopolysaccharide
LU
lytic units
MLR
mixed leukocyte response
NK
natural killer cells
PEC
peritoneal cells
sRBC
sheep red blood cells
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1 Presented in part at the 40th Annual Meeting of Society of Toxicology, March 25, 2001, San Francisco, CA [Guo, T. L., McCay, J. A., Zhang, L. X., Karrow, N. A., Brown, R. D., Germolec, D. R. & White, K. L., Jr. (2001) Genistein modulates immune responses and increases host resistance to B16F10 tumor model in adult female B6C3F1 mice. The Toxicologist 60: 138 (abs.)].
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Supported by the funds provided from the Thomas F. Jeffress and Kate Miller Jeffress Memorial Trust and partially from NIEHS contract no. ES-05454.
Copyright © 2001 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.