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Japanese Journal of Clinical Oncology 2005 35(3):154-157; doi:10.1093/jjco/hyi037
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© 2005 Foundation for Promotion of Cancer Research

Case Report

Endometrioid Adenocarcinoma Arising from Endometriosis of the Mesenterium of the Sigmoid Colon

Susumu Kawate1, Izumi Takeyoshi1, Hayato Ikota2, Yuki Numaga1, Yutaka Sunose1 and Yasuo Morishita1

1 Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine and 2 Clinical Department of Pathology, Gunma University Hospital, Maebashi, Japan

For reprints and all correspondence: Izumi Takeyoshi, Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan. E-mail: takeyosi{at}showa.gunma-u.ac.jp

Received August 26, 2004; accepted October 15, 2004

This report presents a case of endometrioid adenocarcinoma arising from endometriosis of the mesenterium of the sigmoid colon following total abdominal hysterectomy and bilateral salpingo-oophorectomy for leiomyoma of the uterus and infiltrating pelvic endometriosis, and hormone replacement therapy. A 62-year-old woman presented with an abdominal tumor. Based on the diagnosis of mesocolonic tumor, sigmoidectomy with lymph node resection was performed. The tumor cells were immunopositive for cytokeratin 7, but negative for cytokeratin 20, and the tumor was histologically diagnosed as endometrioid adenocarcinoma of the mesocolon. Hyperestrogenism has been implicated as a risk factor for the development of cancer from endometriosis. The patient had been receiving high-dose unopposed estrogens for 14 years after a total abdominal hysterectomy and bilateral salpingo-oophorectomy. Physicians should recognize that endometriosis-associated neoplasms are able to cause symptoms or signs such as abdominal and/or pelvic pain, pelvic mass, and vaginal bleeding, especially if the patient has been treated with hormone replacement therapy. It is important to recognize the possibility of tumors arising from endometriosis when evaluating intestinal or mesenteric neoplasms in women, even in the patient who has previously undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy, particularly if the patient has a history of endometriosis and has received hormone replacement therapy.

Key Words: endometrioid adenocarcinoma • endometriosis • mesenterium • sigmoid colon


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