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DNA and Cell Biology
Effects of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells on T and B Lymphocytes from BXSB Mice
To cite this paper:
Weimin Deng, Qin Han, Lianming Liao, Shengguo You, Hongye Deng, Robert C.H. Zhao.
DNA and Cell Biology.
July 1, 2005,
24(7): 458-463.
doi:10.1089/dna.2005.24.458.
Weimin Deng Department of Immunology, Peking University Health Science Centre, Beijing, People's Republic of China. Centre for Tissue Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People's Republic of China. Department of Immunology, Tianjin Medical University, Tianjin, People's Republic of China. Qin Han Centre for Tissue Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People's Republic of China. Lianming Liao Centre for Tissue Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People's Republic of China. Shengguo You Centre for Tissue Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People's Republic of China. Professor Hongye Deng Department of Immunology, Peking University Health Science Centre, Beijing, People's Republic of China. Robert C.H. Zhao Centre for Tissue Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, People's Republic of China. Bone marrow-derived mesenchymal stem cells (bMSCs) can differentiate into a number of different cell/tissue types, and also possess immunoregulatory functions. The present study was undertaken to elucidate the exact immunoregulatory effects of allogeneic bMSCs on T- and B-lymphocyte proliferation, activation, and function maturation of BXSB mice, which has been considered as a experimental model for human systemic lupus erythematosus (SLE). We determined that bMSCs from BALB/c mice had inhibitory effects on BXSB mice T-lymphocyte proliferation, but no inhibitory effect on their activation. In addition, they had a significant inhibitory and stimulatory effect on IL-4– and IFN-gamma–producing T cells, respectively. Also, bMSCs had inhibitory effects on the proliferation, activation, and IgG secretion of B lymphocytes. In addition, BALB/c bMSCs had an enhancing effect on CD40 expression and inhibitory effects on CD40 ligand (CD40L) ectopic hyperexpression on B cells from BXSB mice.  This paper was cited by:Immunomodulatory effect of mesenchymal stromal cells: possible mechanisms A Nasef, N Ashammakhi, L Fouillard Regenerative Medicine. Aug 2008, Vol. 3, No. 4: 531-546 CrossRef Immune Modulation by Mesenchymal Stem Cells Francesco Bifari, Veronica Lisi, Elda Mimiola, Annalisa Pasini, Mauro Krampera Transfusion Medicine and Hemotherapy. Feb 2008, Vol. 35, No. 3: 194-204 CrossRef Immunomodulatory properties of mesenchymal stromal cells A. J. Nauta, W. E. Fibbe Blood. Dec 2007, Vol. 110, No. 10: 3499-3506 CrossRef Use of stem cells for the treatment of multiple sclerosis Dimitrios Karussis, Ibrahim Kassis Expert Review of Neurotherapeutics. 2007, Vol. 7, No. 9: 1189 CrossRef Treatment of resistant pure red cell aplasia after major abo-incompatible bone marrow transplantation with human adipose tissue-derived mesenchymal stem cells Baijun Fang, Yongping Song, Robert Chunhua Zhao, Qin Han, Ying Cao American Journal of Hematology. 2007, Vol. 82, No. 8: 772 CrossRef Mesenchymal stem cells in immunoregulation XI CHEN, MARILYN ANN ARMSTRONG, GANG LI Immunology and Cell Biology. 2006, Vol. 84, No. 5: 413 CrossRef Immunoregulatory function of mesenchymal stem cells Antonio Uccelli, Lorenzo Moretta, Vito Pistoia European Journal of Immunology. 2006, Vol. 36, No. 10: 2566 CrossRef |
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