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Objectives: The aim of this study was to ascertain the effects of contralateral acupuncture on brain function using blind-spot mapping.

Design and participants: Forty (40) healthy volunteers in whom the right-side blind spot was larger than the left-side one—which indicates lower left-brain function—were randomly assigned into the following two groups in which electroacupuncture was applied to: (1) the contralateral ST36 acupuncture point (right side), and (2) the ipsilateral ST36 acupuncture point (left side).

Outcome measure: Blind-spot perimetry length was the outcome measure.

Results: Electroacupuncture to the contralateral side decreased the blind-spot perimetry length by 5.0 (−9.3 to 0.9) [median (interquartile range, IQR)], whereas that to the ipsilateral side increased the length by 4.5 (−3.7 to 7.8) [median, IQR]. There was significant difference in this length between the two groups (p < 0.05).

Conclusions: These results suggest that electroacupuncture application increased or decreased the brain function— as assessed by changes to the blind spot—depending on the treatment side: Contralateral-side treatment has a better effect than ipsilateral-side treatment on brain function. However, further randomized studies that include both right- and left-side–enlarged subjects with a sham needle are needed to convincingly show the effects of contralateral acupuncture on brain function.