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15 August 2008

Volume 47, Number 4
Clinical Infectious Diseases 2008;47:542–553
© 2008 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2008/4704-0018$15.00
DOI: 10.1086/590150
AGING AND INFECTIOUS DISEASES INVITED ARTICLE

Workshop on HIV Infection and Aging: What Is Known and Future Research Directions

Rita B. Effros,1

Courtney V. Fletcher,2

Kelly Gebo,3

Jeffrey B. Halter,6

William R. Hazzard,7

Frances McFarland Horne,8

Robin E. Huebner,4

Edward N. Janoff,9

Amy C. Justice,10

Daniel Kuritzkes,11

Susan G. Nayfield,5

Susan F. Plaeger,4

Kenneth E. Schmader,13

John R. Ashworth,8

Christine Campanelli,15

Charles P. Clayton,8

Beth Rada,12

Nancy F. Woolard,14 and

Kevin P. High14,a

1David Geffen School of Medicine at the University of California, Los Angeles; 2Health Sciences Center, University of Nebraska, Omaha; 3Johns Hopkins University School of Medicine, Baltimore, and 4National Institute of Allergy and Infectious Diseases and 5National Institute on Aging, Bethesda, Maryland; 6University of Michigan Medical School, Ann Arbor; 7Veterans Affairs Puget Sound Health Care System, Seattle, Washington; 8Association of Specialty Professors, Washington, DC; 9Mucosal and Vaccine Research Program Colorado, University of Colorado School of Medicine, Denver; 10Yale University, West Haven, Connecticut; 11Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts; 12Infectious Diseases Society of America, Arlington, Virginia; 13Duke University School of Medicine, Durham, and 14Wake Forest University School of Medicine, Winston-Salem, North Carolina; and 15American Geriatrics Society, New York, New York

Highly active antiretroviral treatment has resulted in dramatically increased life expectancy among patients with HIV infection who are now aging while receiving treatment and are at risk of developing chronic diseases associated with advanced age. Similarities between aging and the courses of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome suggest that HIV infection compresses the aging process, perhaps accelerating comorbidities and frailty. In a workshop organized by the Association of Specialty Professors, the Infectious Diseases Society of America, the HIV Medical Association, the National Institute on Aging, and the National Institute on Allergy and Infectious Diseases, researchers in infectious diseases, geriatrics, immunology, and gerontology met to review what is known about HIV infection and aging, to identify research gaps, and to suggest high priority topics for future research. Answers to the questions posed are likely to help prioritize and balance strategies to slow the progression of HIV infection, to address comorbidities and drug toxicity, and to enhance understanding about both HIV infection and aging.

Received 4 March 2008; accepted 1 May 2008; electronically published 15 July 2008.

Reprints or correspondence: Dr. Kevin P. High, Section on Infectious Diseases, Dept. of Internal Medicine, Wake Forest University School of Medicine, 100 Medical Center Blvd., Winston-Salem, NC 27157-1042 ().

Kevin P. High, Section Editor

Cited by

M. Lichterfeld, D. Mou, T. D. H. Cung, K. L. Williams, M. T. Waring, J. Huang, F. Pereyra, A. Trocha, G. J. Freeman, E. S. Rosenberg, B. D. Walker, X. G. Yu. (2008) Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood 112:9, 3679-3687
Online publication date: 1-Dec-2008.
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Online publication date: 22-Nov-2008.
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  • aFor the workshop attendees.

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