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1 February 2007

Volume 44, Number 3
Clinical Infectious Diseases 2007;44:456–458
© 2006 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2007/4403-0026$15.00
DOI: 10.1086/510748
HIV/AIDS BRIEF REPORT

Clinical Utility of HIV Standard Genotyping among Antiretroviral-Naive Individuals with Unknown Duration of Infection

Davey Smith,1,2

Niousha Moini,1

Rick Pesano, 3

Edward Cachay,1

Heidi Aiem,1

Yolanda Lie,3

Douglas Richman,1,2 and

Susan Little1

1University of California, San Diego, and 2Veterans Administration San Diego Healthcare System, San Diego, and 3Monogram Biosciences, South San Francisco, California

In clinical settings, we have found a high rate of human immunodeficiency virus (HIV) drug resistance among antiretroviral-naive patients for whom the duration of infection was unknown. These high rates were most likely the result of both transmitted resistance and informal antiretroviral use, and they suggest that routine resistance testing among antiretroviral-naive patients would be a cost-effective clinical practice.

Received 23 August 2006; accepted 2 October 2006; electronically published 28 December 2006.

Reprints or correspondence: Dr. Davey Smith, Antiviral Research Center, University of California, San Diego, 150 W. Washington St., San Diego, CA 92103 ().

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