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1 February 2006

Volume 193, Number 3
The Journal of Infectious Diseases 2006;193:451–454
0022-1899/2006/19303-0016$15.00
DOI: 10.1086/499435
BRIEF REPORT

GB Virus C Replicates in Primary T and B Lymphocytes

Sarah L. George,1,2

Dino Varmaz,1 and

Jack T. Stapleton2

1Research Service and Department of Internal Medicine, Saint Louis University Hospital and St. Louis Veterans Affairs Medical Center, St. Louis, Missouri; 2Research Service and Department of Internal Medicine, Iowa City Veterans Affairs Medical Center and the University of Iowa, Iowa City, Iowa

GB virus C (GBV-C) infection is common in humans and may persist for decades, although most infected persons clear the virus and subsequently develop antibodies to the envelope glycoprotein. GBV-C replicates in peripheral blood mononuclear cells (PBMCs) and CD4+ T lymphocytes in vitro, and depletion of CD4+ T lymphocytes has been proposed as the reason for clearance of GBV-C among persons positive for human immunodeficiency virus. We identified GBV-C RNA in purified CD4+ and CD8+ T lymphocytes and CD19+ B lymphocytes removed ex vivo from infected donors and found that GBV-C replicated in vitro in these PBMC subsets, suggesting that GBV-C is a panlymphotropic virus.

Received 30 June 2005; accepted 1 September 2005; electronically published 28 December 2005.

Reprints or correspondence: Dr. Sarah L. George, Div. of Infectious Diseases, Saint Louis University Hospital, FDT-8N, 3635 Vista Ave., St. Louis, MO 63110 ().

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E Handelsman, I Cheng, B Thompson, R Hershow, LM Mofenson, FB Hollinger, KT Chen, SK Burchett, D Klinzman, JT Stapleton, . (2007) Impact of GB virus type C infection on mother-to-child HIV transmission in the Women and Infants Transmission Study Cohort. HIV Medicine 8:8, 561-567
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  • Presented in part: 12th International Symposium on HCV and Related Viruses, Heidelberg, Germany, 3–6 October 2004 (abstract P-51).

    Financial support: Department of Veterans Affairs (Advanced Career Development Award to S.L.G. and Merit Review Grant to J.T.S.); National Institutes of Health (grant AI-058740 to J.T.S.).

    Potential conflicts of interest: J.T.S. holds a patent describing an infectious GB virus C clone; all other authors: no conflicts reported.

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