All Journals > The Journal of Infectious Diseases > 1 July 2005 > Inhibition of HIV-1 by Measles via Cytokines

Article Tools

Search for Related Articles

  • By Author
  • Search In

Press Release

Unique Collaboration Charts the Migrations of a Parasite that Affected History
Researchers Sequence Louse DNA from Mummies and Propose New Model for its Development


In the News

Featured in Scientific American
"Stomach Bug May Ward Off Asthma" July 16, 2008
Helicobacter pylori Colonization Is Inversely Associated with Childhood Asthma
Yu Chen, Martin J. Blaser
"...scientists analyzed data from more than 7,000 participants in a national health and nutrition survey. They found that children between the ages of three and 13 are less than half as likely to have asthma if they carry H. pylori. They also had half the incidence of hay fever and other allergies. The results appear online in the July 15th issue of The Journal of Infectious Diseases."

Featured in U.S. News & World Report
"Stomach Germ May Protect Against Asthma" July 15, 2008
Helicobacter pylori Colonization Is Inversely Associated with Childhood Asthma

Yu Chen, Martin J. Blaser
"A stomach bacterium called Helicobacter pylori may reduce a child's risk of developing asthma by as much as 50 percent, a new study suggests.  H. pylori has been present in the human stomach probably since humans were humans. However, the germ began disappearing over the course of the 20th century with the introduction of antibiotics and cleaner water and homes, perhaps making children more susceptible to asthma, the study authors suggested."

Featured in Wired News
"Internal Bacterial Imbalance Leads to Asthma" July 15, 2008
Helicobacter pylori Colonization Is Inversely Associated with Childhood Asthma
Yu Chen, Martin J. Blaser
"In a study published yesterday in the Journal of Infectious Diseases, researchers showed that Heliobacter pylori, an intestinal microbe that co-evolved with humans, appears to protect children from asthma.  Asthma rates have nearly doubled in the United States since 1970, and are swelling in the developing world. Underlying the rise is a constellation of causes -- and one of these may be the loss of H. pylori, a vanishing member of the rich bacterial ecosystems in our stomachs."

Featured in Reuters
"Zinc reduces common cold symptoms" April 17, 2008
Duration and Severity of Symptoms and Levels of Plasma Interleukin-1 Receptor Antagonist, Soluble Tumor Necrosis Factor Receptor, and Adhesion Molecules in Patients with Common Cold Treated with Zinc Acetate
Ananda S. Prasad, Frances W. J. Beck, Bin Bao, Diane Snell, and James T. Fitzgerald
Zinc acetate lozenges taken within 24 hours of developing symptoms of the common cold reduce the duration and severity of symptoms, according to a report in The Journal of Infectious Diseases.

Featured in National Public Radio
"Peruvian Mummies' Lice Came from Africa" February 7, 2008
Molecular Identification of Lice from Pre-Columbian Mummies

Didier Raoult, David L. Reed, Katharina Dittmar, Jeremy J. Kirchman, Jean-Marc Rolain, Sonia Guillen, and Jessica E. Light
When humans migrated out of Africa 100,000 years ago, they were likely carrying stowaways. Scientists who've tested head lice taken from Peruvian mummies found the strains of these little parasites were nearly identical to those that were irritating our ancestors in Africa.

Featured in New York Times
"Scientists Say Mummies' Lice Show Pre-Columbian Origins" February 7, 2008
Molecular Identification of Lice from Pre-Columbian Mummies
Didier Raoult, David L. Reed, Katharina Dittmar, Jeremy J. Kirchman, Jean-Marc Rolain, Sonia Guillen, and Jessica E. Light
[In a new paper for the JID, scientists] establish that lice had accompanied their human hosts in the original peopling of the Americas, probably as early as 15,000 years ago. The DNA matched that of the most common type of louse known to exist worldwide now and also before Europeans colonized the New World.

Featured in Reuters
"Head lice came with us out of Africa" February 6, 2008
Molecular Identification of Lice from Pre-Columbian Mummies
Didier Raoult, David L. Reed, Katharina Dittmar, Jeremy J. Kirchman, Jean-Marc Rolain, Sonia Guillen, and Jessica E. Light
Head lice taken from 1,000-year-old mummies in Peru support the idea that the little creatures accompanied humans on their first migration out of Africa, 100,000 years ago, researchers reported on Wednesday.

1 July 2005

Volume 192, Number 1
The Journal of Infectious Diseases 2005;192:71–78
0022-1899/2005/19201-0012$15.00
DOI: 10.1086/430743
MAJOR ARTICLE

Inhibition of HIV-1 Replication in Human Lymphoid Tissues Ex Vivo by Measles Virus

Jean-Charles Grivel,1

Mayra García,2,3

William J. Moss,2,4 and

Leonid B. Margolis1

1Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, Bethesda, 2W. Harry Feinstone Department of Molecular Microbiology and Immunology and 3Cellular Molecular Medicine, School of Medicine, Johns Hopkins University, and 4Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland

Human immunodeficiency virus (HIV) type 1 replication and disease progression are enhanced by various pathogens in coinfected individuals. However, acute infection with measles virus (MV) has been found to suppress HIV-1 replication in coinfected children. We investigated the mechanisms of this phenomenon using human lymphoid tissues coinfected ex vivo with HIV-1 and MV. MV inhibited both CXCR4-tropic (X4) and CCR5-tropic (R5) HIV-1, but the inhibitory effect was particularly profound for R5 virus, which transmits infection and dominates the early stages of HIV-1 disease. MV inhibits the replication of R5 HIV-1 in coinfected tissues by up-regulation of the CC chemokine RANTES, a well-known inhibitor of R5 HIV-1 infection, and this up-regulation is augmented in tissues coinfected with R5 HIV-1. Deciphering the molecular mechanisms by which MV and other pathogens alter local cytokine/chemokine networks and cause tissue microenvironments to become detrimental to HIV-1 may significantly contribute to the development of effective anti-HIV therapies.

Received 18 December 2004; accepted 9 February 2005; electronically published 31 May 2005.

Reprints or correspondence: Dr. Leonid B. Margolis, NIH, Bldg. 10, Rm. 9D58, 10 Center Dr., Bethesda, MD 20892 (); Dr. William J. Moss, Bloomberg School of Public Health, JHU, 615 N. Wolfe St., Rm. E6545, Baltimore, MD 21205 ().

Cited by

Theodore D Ruel, Jane Achan, Anne F Gasasira, Edwin D Charlebois, Tsedal Mehbratu, Philip J Rosenthal, Grant Dorsey, Moses R Kamya, Adeodata Kekitiinwa, Joseph Wong, Diane V Havlir. (2008) HIV RNA Suppression Among HIV-Infected Ugandan Children With Measles. JAIDS Journal of Acquired Immune Deficiency Syndromes 48:2, 225-227
Online publication date: 1-Jul-2008.
CrossRef
M. Garcia, X.-F. Yu, D. E. Griffin, W. J. Moss. (2008) Measles virus inhibits human immunodeficiency virus type 1 reverse transcription and replication by blocking cell-cycle progression of CD4+ T lymphocytes. Journal of General Virology 89:4, 984-993
Online publication date: 1-May-2008.
CrossRef
Angélique Biancotto, Sarah J. Iglehart, Andrea Lisco, Christophe Vanpouille, Jean-Charles Grivel, Nell S. Lurain, Patricia S. Reichelderfer, Leonid B. Margolis. (2008) Upregulation of Human Cytomegalovirus by HIV Type 1 in Human Lymphoid Tissue ex Vivo. AIDS Research and Human Retroviruses 24:3, 453-462
Online publication date: 1-Apr-2008.
CrossRef
Cristian Condack, Jean-Charles Grivel, Patricia Devaux, Leonid Margolis, and Roberto Cattaneo. (2007) Measles Virus Vaccine Attenuation: Suboptimal Infection of Lymphatic Tissue and Tropism Alteration. The Journal of Infectious Diseases 196:4, 541-549
Online publication date: 15-Aug-2007.
  • Financial support: National Institute of Child Health and Human Development Intramural Program (to J.-C.G. and L.B.M.); Elizabeth Glaser Pediatric AIDS Foundation (grant PG-51331 to M.G. and W.J.M.).

Close Popup