Clinical Infectious Diseases 2004;39:1852–1855
© 2004 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2004/3912-0019$15.00
DOI: 10.1086/426078
HIV/AIDS BRIEF REPORT
Immune Reconstitution Inflammatory Syndrome Associated with Kaposi Sarcoma during Potent Antiretroviral Therapy
Elizabeth Connick,1
Madeleine A. Kane,3
Irene E. White,1
John Ryder,2 and
Thomas B. Campbell1
1Division of Infectious Diseases and 2Department of Pathology, University of Colorado Health Sciences Center, and 3Medical Oncology Section, Denver Veterans Affairs Medical Center and University of Colorado Cancer Center, Denver, Colorado
Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4+ lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4+ lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy.
Received 7 June 2004; accepted 10 August 2004; electronically published 19 November 2004.
Reprints or correspondence: Dr. Elizabeth Connick, University of Colorado Health Sciences Center, Box B168, 4200 E. 9th Ave., Denver, CO 80262 (
liz.connick@uchsc.edu).
Cited by
Rasha Ali, Jae Yong Kim, Bonnie An Henderson. (2008) Adnexal and Anterior Segment Manifestations of HIV/AIDS.
International Ophthalmology Clinics 47:2, 15-32
Online publication date: 1-Oct-2008.
CrossRef Luc Kestens, Nabila Seddiki, Paul R Bohjanen. (2008) Immunopathogenesis of immune reconstitution disease in HIV patients responding to antiretroviral therapy.
Current Opinion in HIV and AIDS 3:4, 419-424
Online publication date: 1-Aug-2008.
CrossRef Graeme Meintjes, Lut Lynen. (2008) Prevention and treatment of the immune reconstitution inflammatory syndrome.
Current Opinion in HIV and AIDS 3:4, 468-476
Online publication date: 1-Aug-2008.
CrossRef Ramesh V Nathan. (2007) Suspected immune reconstitution inflammatory syndrome associated with the proliferation of Kaposi??s sarcoma during HAART.
AIDS 21:6, 775
Online publication date: 1-Apr-2007.
CrossRef Martyn A. French. (2007) Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy.
Current HIV/AIDS Reports 4:1, 16-21
Online publication date: 1-Mar-2007.
CrossRef Joseph G Sinkovics. (2007) Adult human sarcomas. I. Basic science.
Expert Review of Anticancer Therapy 7:1, 31-56
Online publication date: 1-Feb-2007.
CrossRef Emil Lesho. (2006) Evidence base for using corticosteroids to treat HIV-associated immune reconstitution syndrome.
Expert Review of Anti-infective Therapy 4:3, 469-478
Online publication date: 1-Jul-2006.
CrossRef Jessica R Grubb, Anne C Moorman, Rose K Baker, Henry Masur. (2006) The changing spectrum of pulmonary disease in patients with HIV infection on antiretroviral therapy.
AIDS 20:8, 1095???1107
Online publication date: 1-Jun-2006.
CrossRef Manuel Battegay, Henning Drechsler. (2006) Clinical spectrum of the immune restoration inflammatory syndrome.
Current Opinion in HIV and AIDS 1:1, 56-61
Online publication date: 1-Feb-2006.
CrossRef Rom S. Leidner, David M. Aboulafia. (2005) Recrudescent Kaposi's Sarcoma After Initiation of HAART: A Manifestation of Immune Reconstitution Syndrome.
AIDS Patient Care and STDs 19:10, 849-858
Online publication date: 1-Nov-2005.
CrossRef Rom S. Leidner, David M. Aboulafia. (2005) Recrudescent Kaposi's Sarcoma After Initiation of HAART: A Manifestation of Immune Reconstitution Syndrome.
AIDS Patient Care and STDs 19:10, 635-644
Online publication date: 1-Nov-2005.
CrossRef Carmen Ares, Abdelkarim S Allal. (2005) Long-term complete remission of laryngeal Kaposi's sarcoma after palliative radiotherapy.
Nature Clinical Practice Oncology 2:9, 473-477
Online publication date: 1-Oct-2005.
CrossRef 
