Coniothyren: a new phenoxyphenyl ether from the endophytic fungus, Coniothyrium sp.

Hidayat HussainDepartment of Chemistry, University of Paderborn, Paderborn33098, Germany;UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa 616, Sultanate of OmanCorrespondencehidayat110@gmail.com K.Krohn@upb.de

Ines KockDepartment of Chemistry, University of Paderborn, Paderborn33098, Germany

Ahmed Al-HarrasiUoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa 616, Sultanate of Oman

Ghulam AbbasUoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa 616, Sultanate of Oman;Department of Chemistry, CIIT, Abbottabad Campus, Abbottabad22060, Pakistan

Najeeb Ur RehmanUoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa 616, Sultanate of Oman

Afzal ShahDepartment of Chemistry, Quaid-i-Azam University, Islamabad45320, Pakistan

Amin BadshahDepartment of Chemistry, Quaid-i-Azam University, Islamabad45320, Pakistan

Usman Ali RanaDeanship of Scientific Research, College of Engineering, King Saud University, Riyadh11421, Saudi Arabia

Zakira NoureenUoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa 616, Sultanate of Oman

Ivan R. GreenDepartment of Chemistry and Polymer Science, University of Stellenbosch, P/Bag X1, Matieland7602, South Africa

Siegfried DraegerInstitute of Microbiology, University of Braunschweig, Braunschweig38106, Germany

Barbara SchulzInstitute of Microbiology, University of Braunschweig, Braunschweig38106, Germany

Karsten KrohnDepartment of Chemistry, University of Paderborn, Paderborn33098, GermanyCorrespondencehidayat110@gmail.com K.Krohn@upb.de

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Abstract

Phytochemical investigation of the endophytic fungus Coniothyrium sp. resulted in the isolation of a new phenoxyphenyl ether, named coniothyren (1), and two known compounds, coniol (2) and (+)-epoxydon (3). The structure of the new compound was elucidated by detailed spectroscopic analysis, namely, ¹H NMR, ¹³C NMR, COSY, HMQC, HMBC, and HR-EI-MS. Preliminary studies demonstrated that (+)-epoxydon (3) displayed good antibacterial and antialgal activities toward Bacillus megaterium and Chlorella fusca, respectively.

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Acknowledgments

The authors thank BASF AG and the BMBF (Bundesministerium für Bildung und Forschung, project no. 03F0360A).

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Coniothyren: a new phenoxyphenyl ether from the endophytic fungus, Coniothyrium sp.

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Coniothyren: a new phenoxyphenyl ether from the endophytic fungus, Coniothyrium sp.

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