New insights into the control of cell growth; the role of the Axl family
References (43)
- et al.
Signal transdnction by receptors with tyrosine kinase activity
Cell
(1990) - et al.
Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis
Blood
(1994) - et al.
An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system
Neuron
(1991) - et al.
rse, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain
J Biol Chem
(1994) - et al.
Analysis of the murine Dtk gene identifies conservation of genomic structure within a new receptor tyrosine kinase family
Genomics
(1996) - et al.
The proto-oncogene of v-eyk(v-ryk) is a novel receptor-type protein tyrosine kinase with extracellular Ig/FN-III domains
J Biol Chem
(1994) - et al.
The anticoagulation factor protein S and its relative, Gas6, are ligands for the tyro 3/Axl family of receptor tyrosine kinases
Cell
(1995) - et al.
Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3
Cell
(1995) - et al.
Stimulation of Sky receptor tyrosine kinase by the product of growth-arrest-specific gene
6. J Biol Chem
(1995) - et al.
Characterisation of Gas6, a member of the superfamily of G domain-containing proteins as a ligand for Rse and Axl
J Biol Chem
(1996)
Agrin acts via a MuSK receptor complex
Cell
Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase
Biochem Biophys Res Commun
Mouse mammary tumors express elevated levels of RNA encoding the murine homolog of SKY, a putative receptor tyrosine kinase
J Biol Chem
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
Cell
They’re not just for clots anymore
Current Biol
Receptor tyrosine kinases and their signal transduction pathways
Annu Rev Cell Biol
Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
Mol Cell Biol
A novel putative tyrosine kinase receptor with oncogenic potential
Oncogene
A putative receptor tyro-sine kinase with unique structural topology
Oncogene
The murine ufo receptor: molecular cloning, chromosomal localization and in situ expression analysis
Oncogene
The receptor tyrosine kinase ARK mediates celt aggregation by homophilic binding
Mol Cell Biol
Cited by (52)
The role of TAM family receptors and ligands in the nervous system: From development to pathobiology
2018, Pharmacology and TherapeuticsCitation Excerpt :Gas6 was cloned following its up-regulation in confluent cell lines where it protected cells from death after complete serum withdrawal, in the absence of significant DNA synthesis (Bellosta et al., 1997; Goruppi et al., 1999; Schneider, King, & Philipson, 1988; Stitt et al., 1995; Varnum et al., 1995). Gas6 is widely expressed in the CNS where it has important physiologically relevant functions (Allen et al., 1999; Avanzi et al., 1998; Crosier & Crosier, 1997; Fourgeaud et al., 2016; Healy et al., 2016; Prieto et al., 2000). Gas6 is expressed in and secreted by neurons including Purkinje cells in the cerebellum (Allen et al., 1999; Prieto et al., 2000).
Axl-/- mice have delayed recovery and prolonged axonal damage following cuprizone toxicity
2008, Brain ResearchCitation Excerpt :The ligand for Axl is growth arrest-specific protein 6 (Gas6) (Bellosta et al., 1997; Goruppi et al., 1999). Gas6 is widely expressed in the nervous system, and is secreted by neurons and endothelial cells (Stitt et al., 1995; Varnum et al., 1995; Crosier and Crosier, 1997; Avanzi et al., 1998; Allen et al., 1999; Prieto et al., 2000); Gas6 is concentrated along the plasma membrane in resting endothelial cells (EC) (Avanzi et al., 1998). The relative affinity of Gas6 for Axl, Tyro3, and Mer receptors is Axl > Tyro3 > Mer.
The anticoagulant protein C pathway
2005, FEBS LettersMolecular mechanisms of gonadotropin-releasing hormone neuronal migration
2004, Trends in Endocrinology and MetabolismLigand recognition and homophilic interactions in Tyro3: Structural insights into the Axl/Tyro3 receptor tyrosine kinase family
2004, Journal of Biological ChemistryMacrophage regulation by Tyro 3 family receptors
2003, Current Opinion in Immunology