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Pancreatic B-cell dysfunction and glucose toxicity in non-insulin-dependent diabetes

Published online by Cambridge University Press:  18 April 2008

Peter R. Flatt
Affiliation:
School of Biomedical SciencesUniversity of UlsterColeraineBT52 1SA
Yasser H. A. Abdel-Wahab
Affiliation:
School of Biomedical SciencesUniversity of UlsterColeraineBT52 1SA
Alison C. Boyd
Affiliation:
School of Biomedical SciencesUniversity of UlsterColeraineBT52 1SA
Christopher R. Barnett
Affiliation:
School of Biomedical SciencesUniversity of UlsterColeraineBT52 1SA
Finbarr P. M. O'Harte
Affiliation:
School of Biomedical SciencesUniversity of UlsterColeraineBT52 1SA
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Abstract

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Type
Symposium on ‘Diabetes towards the year 2000’
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Abdel-Halim, S. M. Ostenson, C.-G. Andersson, A. Jansson, L. & Efendic, S. (1995). A defective stimulus-secretion coupling rather than glucotoxicity mediates the impaired insulin secretion in mildly diabetic F1 hybrids of GK-Wistar rats Diabetes 44 12801284.CrossRefGoogle ScholarPubMed
Abdel-Wahab, Y. H. A. Barnett, C. R. & Flatt, P. R. (1993). Characteristics of extracellular and intracellular glycation. of insulin Diabetic Medicine 9 Suppl. 2 S12S13.Google Scholar
Abdel-Wahab, Y. H. A. O'Harte, F. P. M. Barnett, C. R. & Flatt, P. R. (1994). Studies on the effect of glycation of insulin on biological action in isolated mouse diaphragm muscle Biochemical Society Transactions 22 238S.CrossRefGoogle Scholar
Abdel-Wahab, Y. H. A. O'Harte, F. P. M. Barnett, C. R. & Flatt, P. R. (1997). Characterisation of insulin glycation in insulin-secreting cells maintained in tissue culture Journal of Endocrinology 152 5967.CrossRefGoogle ScholarPubMed
Abdel-Wahab, Y. H. A. O'Harte, F. P. M. Ratcliff, H. McClenaghan, N. H. Barnett, C. R. & Flatt, P. R. (1996). Glycation of insulin in the islets of Langerhans of normal and diabetic animals Diabetes 45 14891496.CrossRefGoogle ScholarPubMed
Anello, M. Rabazzo, A. M. Degano, C. Caltabiano, V. Patane, G. Vigneri, R. & Purrello, F. (1996). Fast reversibility of glucose-induced desensitization in rat pancreatic islets: Evidence for an involvement of ion fluxes Diabetes 45 502506.CrossRefGoogle Scholar
Bailey, C. J. & Flatt, P. R. (1988). The enteroinsular axis in models of hyperinsulinaemic and hypoinsulinaemic diabetes. In Frontiers in Diabetes Research: Lessons from Animal Diabetes vol. 2 217224 Shafrir, E. Renold, A. E. Chichester: John LibbeyGoogle Scholar
Barnett, C. R. Wilson, A. M. McClenaghan, N. H. Yoon, T. W. Swanston-Flatt, S. K. Ah-Sing, E. & Flatt, P. R. (1993). Effects of chronic hyperglycaemia on the function of insulin-secreting cells maintained in tissue culture Diabetic Medicine 10 Suppl. 3S24.Google Scholar
Bedoya, F. J. & Jeanrenaud, B. (1991). Insulin secretory response to glucose by perifused islets from lean (fa/fa) rats chronically infused with glucose Diabetes 40 1519.CrossRefGoogle ScholarPubMed
Berggren, P.-O. Rorsman, P. Efendic, S. Ostenson, C.-G. Flatt, P. R. Nilsson, T. Arkhammar, P. Juntti-Berggren, L. (1992). Mechanisms of action of entero-insular hormones, islet peptides and neural input on the insulin secretory process. In Nutrient Regulation of Insulin Secretion, pp. 289318 [Flatt, P. R. editor]. London: Portland Press Ltd.Google Scholar
Berglund, O. Sehlin, J. Taljedal, I.-B. (1980). Influence of the murine gene diabetes on rhubidium ion efflux from perifused islets Diabetologia 19 4549.CrossRefGoogle Scholar
Bjorklund, A. & Grill, V. (1993). B-cell insensitivity in vitro: Reversal by diazoxide entails more than one event in stimulus-secretion coupling Endocrinology 132 13191328.CrossRefGoogle ScholarPubMed
Clark, A. (1992). Islet amyloid: An enigma of type 2 diabetes Diabetes Metabolism Reviews 8 117132.CrossRefGoogle ScholarPubMed
Davalli, A. M. Pontiroli, A. E. Socci, C. Bertuzzi, F. Fattor, B. Braghi, S. Di Carlo, V. & Pozza, G. (1992). Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely: Evidence supporting specific desensitization rather than β-cell exhaustion Journal of Clinical Endocrinology and Metabolism 74 790794.CrossRefGoogle Scholar
Diani, A. R. Peterson, T. & Gilchrist, R. J. (1983). Islet innervation of nondiabetic and diabetic Chinese hamsters. I Acetylcholinesterase histochemistry and norepinephrine fluorescence Journal of Neural Transmission 56 223238.CrossRefGoogle ScholarPubMed
Eizirik, D. L. Korbutt, G. S. & Hellerstrom, C. (1992). Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function Journal of Clinical Investigation 90 12631268.CrossRefGoogle ScholarPubMed
Fernandez-Alvarez, J. Conget, I. Rasschaert, J. Sener, A. Gomis, R. & Malaisse, W. J. (1994). Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients Diabetologia 37 177181.CrossRefGoogle ScholarPubMed
Ferrer, J. Aoki, M. Behn, P. Nestorowicz, A. Riggs, A. & Permutt, M. A. (1996). Mitochondrial glycerol-3-phosphate dehydrogenase: Cloning of an alternatively spliced human islet-cell cDNA, tissue distribution, physical mapping, and identification of a polymorphic genetic marker Diabetes 45 262266.CrossRefGoogle ScholarPubMed
Flatt, P. R. (1992). Nutrient Regulation of Insulin Secretion London: Portland Press Ltd.Google Scholar
Flatt, P. R. (1996). Hormonal and neural control of endocrine pancreatic function. In Textbook of Diabetes 2nd ed. 9.19.17 Pickup, J. C. and Williams, G. Oxford: Blackwell.Google Scholar
Flatt, P. R. & Bailey, C. J. (1981). Development of glucose intolerance and impaired plasma insulin response to glucose in obese hyperglycaemic (ob/ob) mice Hormone and Metabolic Research 13 556560.CrossRefGoogle ScholarPubMed
Flatt, P. R. Bailey, C. J. Berggren, P.-O. Herberg, L. & Swanston-Flatt, S. K. (1992). Defective insulin secretion in diabetes and insulinoma Nutrient Regulation of Insulin Secretion. 341386 [Flatt, P. R. editor]. London: Portland Press Ltd.Google Scholar
Flatt, P. R. & Lenzen, S. (1994). Frontiers of Insulin Secretion and Pancreatic B-Cell Research London: Smith-Gordon & Co. Ltd.Google Scholar
Frankel, B. J. & Sehlin, J. (1987). Abnormalities in glucose-stimulated insulin release, 45Ca uptake and 86Rb efflux in diabetic Chinese hamster islets Diabetes 36 648653.CrossRefGoogle ScholarPubMed
Grill, V. Sako, Y. Bjorklund, A. & Inoue, K. (1994). Mechanisms underlying the influence of a diabetic state on pancreatic B-cell function. In Frontiers of Insulin Secretion and Pancreatic B-cell Research, pp. 473479 [Flatt, P. R. Lenzen, S., editors]. London: Smith-Gordon & Co. Ltd.Google Scholar
Havel, P. J. Dunning, B. E. & Taborsky, G. J. Jr (1994). Autonomic control of insulin secretion. In Frontiers of Insulin Secretion and Pancreatic B-Cell Research, pp. 343352 [Flatt, P. R. and Lenzen, S. editors] London: Smith-Gordon & Co. Ltd.Google Scholar
Holst, J. J. (1992). Role of classical and peptidergic neurotransmitters in insulin secretion. Nutrient Regulation of Insulin Secretion, pp. 2339 Flatt, P. R., editor] London: Portland Press Ltd.Google Scholar
Hunter, S. J. Wiggam, M. I. Boyd, A. C. O'Harte, F. P. M. Ennis, C. N. Gamble, R. Sheridan, B. Barnett, C. R. McNulty, H. Bell, P. M. & Flatt, P. R. (1996). Glycation of human insulin reduces us biological potency as assessed by euglycaemic clamps in normal man Diabetic Medicine 13 Suppl. 1SI7.Google Scholar
Iwasaki, N. Kawamura, M. Yamagata, K. Cox, N. J. Karibe, S. Ohgawara, H. Inagaki, N. Seino, S. Bell, G. I. & Omori, Y. (1996). Identification of microsatellite markers near the human genes encoding the B-cell ATP-sensitive K+ channel and linkage studies with NIDDM in Japanese Diabetes 45 267269.CrossRefGoogle Scholar
Iwashima, Y. Pugh, W. Depaoli, A. M. Takeda, J. Seino, S. Bell, G. I. & Polonsky, K. S. (1993). Expression of calcium channel mRNAs in pancreatic islets and down regulation after glucose infusion Diabetes 42 948955.CrossRefGoogle Scholar
Kahn, A. Ostenson, C.-G. & Efendic, S. (1994). Glucose cycling in pancreatic islets. In Frontiers of Insulin Secretion and Pancreatic B-cell Research, pp. 103111 [Flatt, P. R. and Lenzen, S., editors]. London: Smith-Gordon & Co. Ltd.Google Scholar
Kahn, S. E. & Porte, D. Jr (1990). The pathophysiology of type II (non-insulin-dependent) diabetes mellitus: Implications for treatment. Ellenberg and Rifkin's Diabetes Mellitus: Theory and Practise 4th ed., pp. 436456 Rifkin, H. and Porte, D. Jr editors] New York: ElsevierGoogle Scholar
Kaiser, N. Corcos, A. P. Sarel, I. & Cerasi, E. (1991). Monolayer culture of adult rat pancreatic islets on extracellular matrix: Modulation of β-cell function by chronic exposure to high glucose Endocrinology 129 20672076.CrossRefGoogle Scholar
Kloppel, G. Gepts, W. In'tVeld, P. A. (1992). Morphology of the pancreas in normal and diabetic states. International Textbook of Diabetes, pp. 223259 [Alberti, K. G. M. M. Defronzo, R. A. Keen, H. and Zimmet, P. editors]. Chichester: John WileyGoogle Scholar
Leahy, J. L. (1990). Natural history of β-cell dysfunction in NIDDM Diabetes Care 13 9921010.CrossRefGoogle ScholarPubMed
Leahy, J. L. Bumbalo, L. M. & Chen, C. (1993). Diazoxide causes recovery of β-cell glucose responsiveness in 90% pancreatectomized diabetic rats Diabetes 43 173179.CrossRefGoogle Scholar
Lenzen, S. (1992). Glucokinase: Signal recognition enzyme for glucose-induced insulin secretion Nutrient Regulation of Insulin Secretion, pp. 101124 [Flatt, P. R. editors]. London: Portland Press Ltd.Google Scholar
McClenaghan, N. H. Barnett, C. R. Ah-Sing, E. Abdel-Wahab, Y. H. A. O'Harte, F. P. M. Yoon, T.-W. Swanston-Flatt, S. K. & Flatt, P. R. (1996). Characterization of a novel glucose-responsive insulin-secreting cell line, BRIN-BD11, produced by electrofusion Diabetes 45 11321140.CrossRefGoogle ScholarPubMed
MacDonald, M. J. Efendic, S. Ostenson, C.-G. (1996). Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat Diabetes 45 886890.CrossRefGoogle ScholarPubMed
Malaisse, W. J. (1994). Pancreatic B-cell FAD-glycerophosphate dehydrogenase deficiency in non-insulin-dependent diabetes: An up-dated review. In Frontiers of Insulin Secretion and Pancreatic B-cell Research pp. 445452 [Flatt, P. R. and Lenzen, S., editors]. London: Smith-Gordon & Co. Ltd.Google Scholar
Marks, V. Samols, E. & Stagner, J. (1992). Intra-islet interactions. Nutrient Regulation of Insulin Secretion, pp. 4157 [Flatt, P. R. editor]. London: Portland Press Ltd.Google Scholar
Matchinsky, F. M. (1990). Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes Diabetes 39 647652.Google Scholar
Matchinsky, F. M. (1996). A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm Diabetes 45 223241.Google Scholar
Meissner, H. P. & Schmidt, H. (1976). The electrical activity of the pancreatic B-cells of diabetic mice FEBS Letters 67 371374.CrossRefGoogle Scholar
Morgan, L. M. (1992). Insulin secretion and the enteroinsular axis. In Nutrient Regulation of Insulin Secretion, pp. 122 [Flatt, P. R. editor]. London: Portland Press Ltd.Google Scholar
Ogawa, Y. Norma, Y. Davalli, A. M. Wu, Y.-J. Thorens, B. Boner-Weir, S. & Weir, G. C. (1995). Loss of glucose-induced insulin secretion and GLUT2 expression in transplanted B-cells Diabetes 44 7579.CrossRefGoogle Scholar
O'Harte, F. P. M. Hojrup, P. Barnett, C. R. & Flatt, P. R. (1986). Identification of the site of glycation of human insulin Peptides 17 13231330.CrossRefGoogle Scholar
Ohneda, M. Johnson, J. H. Inman, L. R. Chen, L. Suzuki, K.-I. Goto, Y. Alam, T. Ravazzola, M. Orci, L. & Unger, R. H. (1993). GLUT2 expression and function in β-cells of GK rats with NIDDM: Dissociation between reductions in glucose transport and glucose stimulated insulin secretion Diabetes 42 10651072.CrossRefGoogle ScholarPubMed
Orci, L. Lambert, A. E. Amherdt, M. Cameron, D. Kanazawa, Y. & Stauffacher, W. (1970). The autonomic nervous system and the B-cell: Metabolic and morphological observations made in Spiny mice (Acomys cahirinus). Acta Diabetologica 7 Suppl. 1184226.Google ScholarPubMed
Paolisso, G. Gambardella, A. Amato, L. Tortioriello, R. D'Amore, A. Varricchio, M. D'Onofrio, F. (1995). Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects Diabetologia 38 12951299.CrossRefGoogle Scholar
Prentki, M. & Corkey, B. E. (1996). Are the B-cell signalling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes 45 273283.CrossRefGoogle Scholar
Randle, P. J. Priestman, D. A. Mistry, S. & Halsall, A. (1994). Mechanisms modifying glucose oxidation in humans Diabetologia 37 Suppl. 2S155S161.CrossRefGoogle Scholar
Rorsman, P. Arkhammar, P. Bokvist, K. Hellerstrom, C. Nilsson, T. Welsh, M. Welsh, N. Berggren, P.-O. (1989). Failure of glucose to elicit a normal secretory response in fetal pancreatic β-cells results from glucose-insensitivity to the ATP-regulated K+ channels Proceedings of the National Academy of Science? USA 86 45054509.CrossRefGoogle Scholar
Sako, Y. & Grill, V. (1990a). A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B-cell oxidation through a process likely coupled to fatty acid oxidation Endocrinology 127 15801589.CrossRefGoogle ScholarPubMed
Sako, Y. & Grill, V. (1990b). Coupling of β-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin in glucose-infused rats Diabetes 39 15801583.CrossRefGoogle ScholarPubMed
Sener, A. & Malaisse, W. J. (1992). Hexose metabolism in pancreatic islets. Ca2+-dependent activation of the glycerol phosphate shuttle by nutrient secretagogues Journal of Biological Chemistry 267 1325113256.CrossRefGoogle Scholar
Shimada, F. Makino, H. Iwaoka, H. Miyamoto, S. Hashimoto, N. Kanatsuka, A. Bell, G. I. & Yoshida, S. (1995). Identification of two novel amino acid polymorphisms in beta cell/liver (GLUT2) glucose transporter in Japanese subjects Diabetologia 38 211215.CrossRefGoogle ScholarPubMed
Simonson, D. C. Rossetti, L. Giaccari, A. & DeFronzo, R. A. (1992). Glucose toxicity. International Textbook of Diabetes, pp. 635667 [Alberti, K. G. M. M. De Fronzo, R. A. Keen, H. and Zimmet, P. editors]. Chichester: John WileyGoogle Scholar
Stone, L. M. Kahn, S. E. Fujimoto, W. Y. Deeb, S. S. & Porte, D. Jr. (1996). A variation at position – 30 of the β-cell glucokinase gene promoter is associated with reduced B-cell function in middle-aged Japanese-American men Diabetes 45 422428.CrossRefGoogle Scholar
Svensson, C. Sandier, S. & Hellerstrom, C. (1993). Lack of long-term β-cell glucotoxicity in vitro in pancreatic islets isolated from two mouse strains (C57BL/6J; C57BL/KsJ) with different sensitivities of the β-cells to hyperglycaemia in vivo Journal of Endocrinology 136 289296.CrossRefGoogle ScholarPubMed
Tanizawa, Y. Riggs, A. C. Chiu, K. C. Janssen, R. C. Bell, D. S. H. Go, R. P.-C. Roseman, J. M. Acton, R. T. & Permutt, M. A. (1994a). Variability of the pancreatic islet beta cell/liver (GLUT2) glucose transporter gene in NIDDM patients Diabetologia 37 420427.CrossRefGoogle Scholar
Tanizawa, Y. Chiu, K. C. Elbein, S. C. Turner, R. C. & Permutt, M. A. (1994b). Role of glucokinase in the defective insulin secretion of late-onset non-insulin dependent diabetes. Frontiers of Insulin Secretion and Pancreatic B-Cell Research, pp. 437444 Flatt, P. R. and Lenzen, S. editors]. London: Smith-Gordon & Co. Ltd.Google Scholar
Tanizawa, Y. Matsubara, A. Ueda, K. Katagiri, H. Kuwano, A. Ferrer, J. Permutt, M. A. & Oka, Y. (1996). A human pancreatic islet inwardly rectifying potassium channel: cDNA cloning, determination of genomic structure and genetic variations in Japanese NIDDM patients Diabetologia 39 447452.CrossRefGoogle ScholarPubMed
Tatemoto, K. Efendic, S. Mutt, V. Makk, G. Feistner, G. J. & Barchas, J. D. (1986). Pancreastatin. a novel pancreatic peptide that inhibits insulin secretion Nature 324 476478.CrossRefGoogle ScholarPubMed
Thorens, B. Wu, Y.-J. Leahy, J. L. & Weir, G. C. (1992). The loss of GLUT2 expression by glucose-unresponsive β-cells of db/db mice is reversible and is induced by the diabetic environment Journal of Clinical Investigation 90 7785.CrossRefGoogle ScholarPubMed
Tsuura, Y. Ishida, H. Okamoto, Y. Tsuji, K. Kurose, T. Horie, M. Imura, H. Okada, Y. & Seino, Y. (1992a). Impaired glucose sensitivity of ATP-sensitive K+ channels in pancreatic β-cells in streptozotocin-induced NIDDM rats Diabetes 41 861865.CrossRefGoogle ScholarPubMed
Tsuura, Y. Ishida, H. Okamoto, Y. Kato, S. Sakamoto, K. Horie, M. Ikeda, H. Okada, Y. & Seino, Y. (1992b). Glucose sensitivity of ATP-sensitive K+ channels is impaired in β-cells of the GK rat: A new genetic model of NIDDM Diabetes 42 14461456.CrossRefGoogle Scholar
Unger, R. H. (1992). GLUT-2 and the pathogenesis of type II diabetes Diabetes Nutrition and Metabolism 5 6569.Google Scholar
Unger, R. H. (1995). Lipotoxicity in the pathogenesis of obesity-dependent NIDDM, genetic and clinical implications Diabetes 44 863870.CrossRefGoogle ScholarPubMed
Unger, R. H. & Grundy, S. (1985). Hyperglycaemia as an inducer as well as a consequence of impaired islet cell function and insulin resistance: Implications for the management of diabetes Diabetologia 28 119121.CrossRefGoogle ScholarPubMed
Velho, G. Froguel, P. Clement, K. Pueyo, M. E. Rakotoambinina, B. Zouali, H. Passa, P. Cohen, D. & Robert, J. J. (1992). Primary pancreatic beta cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young Lancet 340 444448.CrossRefGoogle ScholarPubMed
Warren-Perry, M. G. Stoffel, M. Saker, P. J. Zhang, Y. Brown, L. J. MacDonald, M. J. & Turner, R. C. (1996). Mitochondrial FAD-glycerophosphate dehydrogenase and G-protein-coupled inwardly rectifying K+ channel: No evidence for linkage in maturity-onset diabetes of the young or NIDDM Diabetes 45 639641.CrossRefGoogle ScholarPubMed
Zhang, Y. Warren-Perry, M. Sakura, H. Adedlman, J. Stoffel, M. Bell, G. I. Aschcroft, F. M. & Turner, R. C. (1995). No evidence for mutations in a putative B-cell ATP-sensitive K+ channel subunit in MODY, NIDDM or GDM Diabetes 44 597600.CrossRefGoogle ScholarPubMed
Zhou, Y. P. Berggren, P.-O. & Grill, V. (1996). A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of B-cell dysfunction in the obese diabetic db/db mouse Diabetes 45 580586.CrossRefGoogle Scholar
Zhou, Y. P. & Grill, V. (1994). Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose-fatty acid cycle Journal of Clinical Investigation 93 870876.CrossRefGoogle ScholarPubMed