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Moderate whisky consumption in combination with an evening meal reduces tryptophan availability to the brain but does not influence performance in healthy volunteers

Published online by Cambridge University Press:  09 March 2007

C. Rob Markus ,
Aafje Sierksma ,
Cees Verbeek ,
Jan J. M. van Rooijen ,
Hamina J. Patel ,
A. Nico Brand  and
Henk F. J. Hendriks
C. Rob Markus*
Affiliation:
University of Maastricht, Department of Experimental Psychology, PO Box 6200 MD Maastricht, The Netherlands TNO Nutrition and Food Research, Department of Target Organ Toxicology, Zeist, The Netherlands
Aafje Sierksma
Affiliation:
TNO Nutrition and Food Research, Department of Nutritional Physiology, Zeist, The Netherlands University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
Cees Verbeek
Affiliation:
TNO Nutrition and Food Research, Department of Food and Food Supplement Analysis, Zeist, The Netherlands
Jan J. M. van Rooijen
Affiliation:
TNO Nutrition and Food Research, Department of Food and Food Supplement Analysis, Zeist, The Netherlands
Hamina J. Patel
Affiliation:
TNO Bibra International Limited, Surrey, UK
A. Nico Brand
Affiliation:
Utrecht University, Department of Health Psychology, Utrecht, The Netherlands
Henk F. J. Hendriks
Affiliation:
TNO Nutrition and Food Research, Department of Nutritional Physiology, Zeist, The Netherlands
*
*Corresponding author: Dr C. R. Markus, fax +31 43 3884199, email, R.Markus@psychology.unimaas.nl
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Abstract

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Brain serotonin (5-HT) synthesis is controlled by nutrients that influence the availability of plasma tryptophan (Trp) as compared with the sum of the other large neutral amino acids (LNAA; Trp:LNAA). Alcohol consumption is found to change mood and performance and this might well be due to alterations in the plasma Trp:LNAA ratio and brain 5-HT. In the present study, we tested whether whisky consumption as part of a meal may alter the plasma Trp:LNAA ratio and influence mood and performance in healthy volunteers. Twenty-four healthy male subjects participated in a within-subjects cross-over study. Subjects consumed whisky (125ml; 40g alcohol) or water (125ml) as part of a standard evening meal. Effects of whisky consumption were tested on mood and choice reaction time and blood samples were taken to measure changes in plasma amino acids, glucose and insulin. The plasma Trp:LNAA ratio showed a significant decline 2h after whisky consumption of alcohol (P<0·001). No effects were found on choice reaction time or mood as compared with the control condition. The present findings reveal that whisky consumption alters available plasma Trp for uptake into the brain, whereas there were no effects on mood and performance.

Keywords

Alcohol5-HydroxytryptamineMoodInformation processingCognition
Type
Review Article
Information
British Journal of Nutrition , Volume 92 , Issue 6 , December 2004 , pp. 995 - 1000
Copyright
Copyright © The Nutrition Society 2004

References

Altman, HJ & Normile, HJ (1998) What is the nature of the role of the serotonergic nervous system in learning and memory: prospects for development of an effective treatment strategy for senile dementia. Neurobiol Aging 9, 627–638.Google Scholar
Badawy, AAB (1996) Tryptophan metabolism and disposition in relation to alcohol and alcoholism. Adv Exp Med Biol 398, 75–82.CrossRefGoogle ScholarPubMed
Badawy, AAB, Morgan, CJ, Lovett, JWT, Bradley, DM & Thomas, DR (1995) Decrease in circulating tryptophan availability to the brain after acute ethanol consumption by normal volunteers: implications for alcohol-induced aggressive behaviour and depression. Pharmacopsychiatry 28, 93–97.CrossRefGoogle Scholar
Badawy, AAB, Morgan, CJ, Thomas, DR & Lovett, JWT (1987) The acute effects of ethanol on the serum concentrations of tryptophan and other constituents in fasting normal male volunteers. Ann Clin Biochem 24, S1-63–S1-65.Google Scholar
Bellisle, F, Blundell, JE, Dye, L, Fantino, M, Fletcher, RJ, Lambert, J, Roberfroid, M, Specter, S, Westenhöfer, J & Westerterp-Plantenga, MS (1998) Functional food science and behaviour and psychological functions. Br J Nutr 80, S173–S193.Google Scholar
Brand, AN (1999) MINDS: tool for research in health psychology and neuropsychology. In Cognitive Ergonomics, Clinical Assessment and Computer-assisted Learning, pp. 155–168 [Brinker, BPLM den, Beek, PJ, Brand, AN and Maarse, FJ, Mulder, LJM, editors]. The Netherlands: Swets & Zeitlinger.Google Scholar
Curzon, G (1985) Effects of food intake on brain transmitter amine precursors and amine synthesis. In Psychopharmacology and Food, pp. 59–70 [Sandler, M and Silverstone, T, editors]. Oxford: Oxford University Press.Google Scholar
Eckardt, MJ, File, SE, Gessa, GL, Grant, KA, Guerri, C, Hoffman, PL, Kalant, H, Koob, GF, Li, TK & Tabakoff, B (1998) Effects of moderate alcohol consumption on the central nervous system. Alcohol Clin Exp Res 22, 998–1040.CrossRefGoogle ScholarPubMed
Fernstrom, JD & Wurtman, RJ (1972) Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178, 414–416.CrossRefGoogle ScholarPubMed
Hendriks, FJ, Veenstra, J, van Tol, A, Groener, JEM & Schaafsma, G (1998) Moderate doses of alcoholic beverages with dinner and postprandial high density lipoprotein composition. Alcohol Alcohol 4, 403–410.CrossRefGoogle Scholar
Koelega, HS (1995) Alcohol and vigilance performance: a review. Psychopharmacology 118, 233–249.CrossRefGoogle ScholarPubMed
LeMarquand, D, Pihl, RO & Benkelfat, C (1994) Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biol Psychiatry 36, 395–421.CrossRefGoogle ScholarPubMed
Liguori, A, D'Agostino, RB, Dworkin, SI, Edwards, D & Robinson, JH (1999) Alcohol effects on mood, equilibrium and simulated driving. Alcohol Clin Exp Res 23, 815–821.CrossRefGoogle ScholarPubMed
Lloyd, HM & Rogers, PJ (1997) Mood and cognitive performance improved by a small amount of alcohol given with a lunchtime meal. Behav Pharmacol 8, 188–195.Google Scholar
McNair, DM, Lorr, M & Dropleman, LF (1971) EITS Manual – Profile of Mood States. San Diego, CA: Educational and Testing Service.Google Scholar
Maes, M & Meltzer, H (1995) The serotonin hypothesis of major depression. In Psychopharmacology: the Fourth Generation of Progress, pp. 933–944 [Bloom, FE and Kupfer, DJ, editors]. New York: Raven Press.Google Scholar
Markus, CR, Olivier, B & de Haan, EHF (2002) Whey protein rich in alpha-lactalbumin increases the plasma Trp/LNAA ratio and improves cognitive performance in stress-vulnerable subjects. Am J Clin Nutr 75, 1051–1056.Google Scholar
Markus, CR, Olivier, B, Panhuysen, G, Van der Gugten, J, Alles, M, Tuiten, A, Westenberg, HGM, Fekkes, D & Koppeschaar, H (2000) The bovine protein alpha-lactalbumin increases the plasma Trp/LNAA ratio, and in vulnerable subjects raises brain serotonin activity and decreases cortisol and mood under stress. Am J Clin Nutr 71, 1536–1544.Google Scholar
Markus, CR, Panhuysen, G, Tuiten, A, Koppeschaar, H, Fekkes, D & Peters, M (1998) Does carbohydrate-rich, protein-poor food prevent a deterioration of mood and cognitive performance of stress-prone subjects when subjected to a stressful task?. Appetite 31, 49–65.CrossRefGoogle ScholarPubMed
Maylor, EA, Rabbitt, PMA, James, GH & Kerr, SA (1992) Effects of alcohol, practice and task complexity on reaction time distributions. Q J Exp Psychol 44, 119–139.Google Scholar
Maylor, EA, Rabbitt, PMA, Sahgal, A & Wright, C (1987) Effects of alcohol on speed and accuracy in choice reaction time and visual search. Acta Psychol (Amst) 65, 147–163.CrossRefGoogle ScholarPubMed
Morgan, CJ & Badawy, AAB (2001) Alcohol-induced euphoria: exclusion of serotonin. Alcohol Alcohol 36, 22–25.Google Scholar
Rosenthal, NE, Genhart, MJ, Caballero, B, Jacobsen, FM, Skwerer, RG, Coursey, RD, Rogers, S & Spring, B (1989) Psychobiological effects of carbohydrate- and protein-rich meals in patients with seasonal affective disorder and normal controls. Biol Psychiatry 25, 1029–1040.CrossRefGoogle ScholarPubMed
Sierksma, A, van der, Gaag, S, van, Tol, A, James, RW & Hendriks, HFJ (2002) Kinetics of HDL cholesterol and paraoxonase activity in moderate alcohol consumers. Alcohol Clin Exp Res 26, 1430–1435.CrossRefGoogle ScholarPubMed
Sternberg, S (1969) Memory-scanning: mental processes revealed by reaction-time experiments. Am Sci 57, 421–457.Google ScholarPubMed
Sternberg, S (1975) Memory scanning: new findings and current controversies. Q J Exp Psychol 27, 1–32.CrossRefGoogle Scholar