Hostname: page-component-848d4c4894-wg55d Total loading time: 0 Render date: 2024-05-23T05:43:25.478Z Has data issue: false hasContentIssue false
  • English
  • Français

Dietary intakes and adipose tissue levels of linoleic acid in peptic ulcer disease

Published online by Cambridge University Press:  09 March 2007

J. Kearney ,
N. P. Kennedy ,
P. W. N. Keeling ,
J. J. Keating ,
Louise Grubb ,
Margaret Kennedy  and
M. J. Gibney
J. Kearney
Affiliation:
Division of Nutritional Sciences, Department of Clinical Medicine, Trinity College Medical School, St James's Hospital, Dublin 8, Republic of Ireland
N. P. Kennedy
Affiliation:
Division of Nutritional Sciences, Department of Clinical Medicine, Trinity College Medical School, St James's Hospital, Dublin 8, Republic of Ireland
P. W. N. Keeling
Affiliation:
Division of Nutritional Sciences, Department of Clinical Medicine, Trinity College Medical School, St James's Hospital, Dublin 8, Republic of Ireland
J. J. Keating
Affiliation:
Division of Nutritional Sciences, Department of Clinical Medicine, Trinity College Medical School, St James's Hospital, Dublin 8, Republic of Ireland
Louise Grubb
Affiliation:
Division of Nutritional Sciences, Department of Clinical Medicine, Trinity College Medical School, St James's Hospital, Dublin 8, Republic of Ireland
Margaret Kennedy
Affiliation:
Division of Nutritional Sciences, Department of Clinical Medicine, Trinity College Medical School, St James's Hospital, Dublin 8, Republic of Ireland
M. J. Gibney
Affiliation:
Division of Nutritional Sciences, Department of Clinical Medicine, Trinity College Medical School, St James's Hospital, Dublin 8, Republic of Ireland
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Adipose tissue levels of linoleic acid were determined from biopsies of subcutaneous abdominal fat of normal healthy controls (n 40) and from two patient groups with endoscopically evaluated non-ulcer dyspepsia (n 40) or peptic ulcer disease (n 38). The level (g/100 g) of adipose tissue linoleic acid in the normal healthy controls (15·0 (sd 4·1)) was significantly (P < 0·05) greater than that in patients with non-ulcer dyspepsia (12·8 (sd 3·5)) and in patients with peptic ulcer disease (11·7 (sd 2·7)). A dietary history revealed a lower intake of linoleic acid and a significantly (P < 0·05) lower intake of dietary fibre (g/d) for both the non-ulcer dyspepsia (15·9 (sd 6·2)) and peptic ulcer disease (15·2 (sd 7·8)) patients compared with normal healthy controls (20·2 (sd 11·2)). Adipose tissue linoleic acid tended to increase with indices of increasing socioeconomic status, although the differences between patient and controls were not confounded by socioeconomic status. Patients with dyspepsia reported more foods causing symptoms (onion, fried foods, alcohol, citrus fruits and spices) and more foods giving relief (milk, bread) compared with control orthopaedic patients.

Keywords

Linoleic acidAdipose tissuePeptic ulcer
Type
Tissue Lipids
Information
British Journal of Nutrition , Volume 62 , Issue 3 , November 1989 , pp. 699 - 706
Copyright
Copyright © The Nutrition Society 1989

References

REFERENCES

Adam, O., Wolfram, C. & Zöllner, N. (1982). Prostaglandin formation in man during intakes of different amounts of linoleic acid in formula diets. Annals of Nutrition and Metabolism 26, 315–323.CrossRefGoogle ScholarPubMed
Bassham, S. & Fletcher, L.R. (1984). Calculation of nutrient intake by microcomputer. Proceedings of the Nutrition Society 44, 36A.Google Scholar
Bender, A.E. & Matthews, D.R. (1981). Adverse reactions to foods. British Journal of Nutrition 46, 403–408.CrossRefGoogle ScholarPubMed
Beynen, A.C. & Katan, M.B. (1985). Rapid sampling and long term storage of subcutaneous adipose tissue biopsies for determination of fatty acid composition. American Journal of Clinical Nutrition 42, 317–322.CrossRefGoogle ScholarPubMed
Black, A.E. (1986). The use of recommended daily allowances to assess dietary adequacy. Proceedings of the Nutrition Society 45, 369–381.CrossRefGoogle ScholarPubMed
Blaton, V., DeBuyzere, M., Declerg, B., Pracetyo, A., Vanderkeller, A., Delanghe, J. & Spincemaille, J. (1984). Effect of polyunsaturated isocaloric fat diets on plasma lipids and fatty acids. Atherosclerosis 53, 9–29.CrossRefGoogle Scholar
Bolton-Smith, C., Gibney, M.J., Gallagher, P.J., Jewell, R. & Hillier, K. (1988). Effect of polyunsaturated fatty acids of the n−3 and n−6 series on lipid composition and eicosanoid synthesis of platelets and aorta and on immunological induction of atherosclerosis in rabbits. Atherosclerosis 72, 29–35.CrossRefGoogle ScholarPubMed
Charnock, J.S., McIntosh, G.H., Abervardena, M.Y. & Russel, G.R. (1985). Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared Marmoset (Callithrix jacchus) after feeding different lipid supplements. Annals of Nutrition and Metabolism 29, 83–94.CrossRefGoogle ScholarPubMed
Crawford, M.A. (1983). Background to essential fatty acids and their prostanoid derivatives. British Medical Bulletin 39, 210–213.CrossRefGoogle ScholarPubMed
Department of Health and Social Security (1980). Inequalities in Health: Report of a Research Working Group (Black Report). London: DHSS.Google Scholar
Dupont, J., Mathias, M.M. & Connally, P.T. (1980). The effects of dietary essential fatty acid concentration upon prostanoid synthesis in rats. Journal of Nutrition 110, 1695–1702.CrossRefGoogle ScholarPubMed
Elson, C.E., Benevenga, N.J., Canty, D.J., Gummer, R.H., Lalich, J.J., Porter, J.W. & Johnston, A.E. (1982). The influence of dietary unsaturated cis- and trans−saturated fatty acids on tissue lipids of swine. Atherosclerosis 40, 115–137.CrossRefGoogle Scholar
Fordyce, M.K., Christanis, A., Kafotos, A., Duncan, R. & Cassady, J. (1983). Adipose tissue fatty acid composition of adolescents in a US–Greece cross-cultural study of coronary heart disease risk factors. Journal of Chronic Disease 36, 481–486.CrossRefGoogle Scholar
Fulton, M., Thomson, M., Elton, R.A., Crown, S., Wood, D.A. & Oliver, M.F. (1988). Cigarette smoking, social class and nutrient intake: relevance to coronary heart disease. European Journal of Clinical Nutrition 42, 797–803.Google ScholarPubMed
Grant, H.W., Palmer, K.R., Kelly, R.W., Wilson, N.H. & Misiervicz, J.J. (1988). Dietary linoleic acid, gastric acid and prostaglandin secretion. Gastroenterology 94, 955–959.CrossRefGoogle ScholarPubMed
Handleman, G.J., Epstein, W.L., Lawrence, J.M., van Kuijk, F. J. G. M. & Dratz, E.A. (1988). Biopsy method for human adipose with vitamin E and lipid measurements. Lipids 23, 598–604.CrossRefGoogle Scholar
Hollander, D & Tarnawski, A. (1986). Dietary essential fatty acids and the decline in peptic ulcer disease–a hypothesis. Gut 27, 239–242.CrossRefGoogle ScholarPubMed
Hollander, D., Tarnawski, A., Ivery, K.J., Van de Freery, A., Zipser, R.D., McKenzie, W.A. & McFarland, W.D. (1982). Arachidonic acid protection of rat gastric mucosa against ethanol injury. Journal of Laboratory and Clinical Medicine 100, 296–308.Google ScholarPubMed
Huang, Y.S., Drummond, R. & Horribim, D.F. (1987). Protective effect of γ-linolenic acid on aspirin-induced gastric haemorrhage in rats. Digestion 36, 36–41.CrossRefGoogle ScholarPubMed
Katan, M.B. & Beynen, A.C. (1981). Linoleic acid consumption and coronary heart disease in USA and UK. Lancet ii, 371.CrossRefGoogle Scholar
Lasserel, M., Mendy, F., Spielman, D. & Jacotot, B. (1985). Effects of different dietary intakes of essential fatty acids on C20:3ω6 and C20:4ω6 levels in human adults. Lipids 20, 227–233.CrossRefGoogle Scholar
Miller, T.A. (1983). Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. American Journal of Physiology 245, G601–G623.Google ScholarPubMed
Paul, A.A. & Southgate, D.A.T. (1978). McCance & Widdowson's The Composition of Foods, 4th ed. London: H. M. Stationery Office.Google Scholar
Plakke, T., Berkel, J., Beynen, A.C., Hermus, R.T.J. & Katan, M.B. (1983). Relationship between the fatty acid composition of the diet and that of subcutaneous adipose tissue in individual human subjects. Human Nutrition: Applied Nutrition 37A, 365–372.Google Scholar
Tarnawski, A., Hollander, D. & Stachura, J. (1985). Is linoleic acid (dietary essential fatty acid) cytoprotective for the gastric mucosa? Gastroenterology 88, 1610Google Scholar
Van Staveren, W.A., Deurenberg, P., Katan, M.B., Burema, J., de Groot, L. & Hoffmans, M.D. (1986). Validity of the fatty acid composition of subcutaneous fat tissue microbiopsies as an estimate of the long-term average fatty acid composition of the diet of separate individuals. American Journal of Epidemiology 123, 455–463.CrossRefGoogle ScholarPubMed
Vas Dias, F.W., Gibney, M.J. & Taylor, T.G. (1982). The effect of polyunsaturated fatty acids of the n−3 and n−6 series on platelet aggregation and platelet and aorta fatty acid composition in rabbits. Atherosclerosis 43, 245–257.CrossRefGoogle ScholarPubMed
Wood, D.A., Butler, S. & Reimersma, R.A. (1984). Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men. Lancet ii, 117–121.CrossRefGoogle Scholar