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Influence of chronic ethanol intake on obesity, liver steatosis and hyperlipidaemia in the Zucker fa/fa rat

Published online by Cambridge University Press:  09 March 2007

C. Karsenty ,
F. Chanussot ,
M. Ulmer  and
G. Debry
C. Karsenty
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I' Université de Nancy I et Unité de Recherches de Nutrition et Diététique de P' INSERM U. 59, 40 rue Lionnois, F-54000 Nancy, France
F. Chanussot
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I' Université de Nancy I et Unité de Recherches de Nutrition et Diététique de P' INSERM U. 59, 40 rue Lionnois, F-54000 Nancy, France
M. Ulmer
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I' Université de Nancy I et Unité de Recherches de Nutrition et Diététique de P' INSERM U. 59, 40 rue Lionnois, F-54000 Nancy, France
G. Debry
Affiliation:
Département de Nutrition et des Maladies Métaboliques de I' Université de Nancy I et Unité de Recherches de Nutrition et Diététique de P' INSERM U. 59, 40 rue Lionnois, F-54000 Nancy, France
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Abstract

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1. The effect of chronic alcohol intoxication on metabolic disturbances and fatty infiltration and degeneration was studied in genetically obese, hyperlipoproteinaemic, fa/fa Zucker rats.

2. Sixteen obese Zucker (fa/fa) rats, sixteen lean Zucker rats (Fa/-)and sixteen Wistar rats, all male rats aged 7–8 weeks, were given either a control (C)diet (13% of energy from protein, 37% from fat, 50% from carbohydrate) or an ethanol (E) diet (13% of energy from protein, 37% from fat, 14% from carbohydrate, 36% from ethanol) for 4 weeks.

3. The fa/fa rats given diet E consumed more energy than those given diet C, but after 4 weeks the weight gains and degrees of obesity were similar for both groups. With both diets, the developed hyperlipidaemia could be explained by the hyperinsulinaemia. Both hypertriglyceridaemia and hypercholesterolaemia were lower in fa/fa rats eating diet E than in those given diet C. Fatty infiltration of the liver, as assessed by hepatic triacylglycerol and cholesterol contents, was observed with both diets, but for fa/fa rats it was less extreme in those given diet E.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 1 , July 1985 , pp. 5 - 13
Copyright
Copyright © The Nutrition Society 1985

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