Hostname: page-component-8448b6f56d-mp689 Total loading time: 0 Render date: 2024-04-18T18:59:09.170Z Has data issue: false hasContentIssue false
  • English
  • Français

Increases in calcium absorption with ingestion of soluble dietary fibre, guar-gum hydrolysate, depend on the caecum in partially nephrectomized and normal rats

Published online by Cambridge University Press:  09 March 2007

Hiroshi Hara ,
Masashi Nagata ,
Atsutane Ohta  and
Takanori Kasai
Hiroshi Hara
Affiliation:
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo 060, Japan
Masashi Nagata
Affiliation:
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo 060, Japan
Atsutane Ohta
Affiliation:
Department of Nutritional Science Centre, Bioscience Laboratories, Meiji Seika Kaisha Ltd, Sakado 350-02, Japan
Takanori Kasai
Affiliation:
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo 060, Japan
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Effects of feeding soluble dietary fibre on apparent Ca absorption and the contribution of the caecum to Ca absorption were examined in five-sixths nephrectomized (NPX)and normal rats with or without caecectomy in four experiments. It is known that Ca absorption is lowered by renal failure. In the first experiment the amounts of femur Ca increased linearly with increasing dietary Ca up to 3·0 g Ca/kg diet in intact rats. Partial nephrectomy decreased apparent Ca absorption in rats fed on diets containing 30 and 4·5 g Ca/kg diet. In the NPX groups, Ca absorption in rats fed on the diet containing guar-gum hydrolysate (GGH; 50 g/kg diet; 3·0 g Ca/kg diet) was significantly higher than that in rats fed on a fibre-free diet, and the increase in Ca absorption with GGH feeding was completely abolished by caecectomy. Also, ingestion of GGH increased Ca absorption in normal rats, but not in normal, caecectomized rats. Mg absorption was also increased with GGH feeding and was decreased with caecaectomyin NPX and normal rats. In experiments which used caecectomized rats, coprophagy wasprevented with an anal cup to avoid re-ingestion of faecal Ca. We conclude that ingestion of the soluble dietary fibre, GGH, increased apparent Ca absorption in NPX and non-NPX rats, and the caecum was responsible for these increases in Ca absorption.

Keywords

CalciumDietary fibreCaecum
Type
General Nutrition
Information
British Journal of Nutrition , Volume 76 , Issue 5 , November 1996 , pp. 773 - 784
Copyright
Copyright © The Nutrition Society 1996

References

REFERENCES

American Institute of Nutrition (1977). Report of the American Institute of Nutrition ad hoc Committee on Standards for Nutritional Studies. Journal of Nutrition 107, 1340–1348.CrossRefGoogle Scholar
American Institute of Nutrition (1980). Second report of the ad hoc Committee on Standards for Nutritional Studies. Journal of Nutrition 110, 1726.CrossRefGoogle Scholar
Annaka, A., Watanabe, E., Sunahara, T. & Ishibashi, T. (1989). Site and rate of absorption and secretion of calcium and phosphorus in laying hens. Bulletin of the Faculty of Agriculture Niigata University 41, 37–44.Google Scholar
Chutkow, J. G. (1964). Sites of magnesium absorption and excretion in the intestinal tract of the rat. Journal of Laboratory and Clinical Medicine 63, 71–79.Google ScholarPubMed
Chutkow, J. G. (1966). Effect of magnesium deficiency on location of the intestinal absorption of magnesium in rats. Proceedings of the Society for Experimental Biology and Medicine 123, 836–840.CrossRefGoogle ScholarPubMed
Coburn, J. W., Koppel, M. H., Brickman, A. S. & Massry, S. G. (1973). Study of intestinal absorption of calcium in patients with renal failure. Kidney International 3, 264–272.CrossRefGoogle ScholarPubMed
Cree, T. C., Wadley, D. M. & Marlett, J. A. (1986). Effect of preventing coprophagy in the rats on neutral detergent fiber digestibility and apparent calcium absorption. Journal of Nutrition 116, 1204–1208.CrossRefGoogle ScholarPubMed
Démigné, C., Levrat, M. & Rémésy, C. (1989). Effects of feeding fermentable carbohydrates on the cecal concentrations of minerals and their fluxes between the cecum and blood plasma in the rat. Journal of Nutrition 119, 1625–1630.CrossRefGoogle ScholarPubMed
Démigné, C. & Rémésy, C. (1985). Stimulation of absorption of volatile fatty acids and minerals in the cecum of rats adapted to a very high fiber diet. Journal of Nutrition 115, 53–60.CrossRefGoogle ScholarPubMed
Donangelo, C. M. & Eggum, B. O. (1986). Comparative effects of wheat bran and barley husk on nutrient Utilization in rats. British Journal of Nutrition 56, 269–280.CrossRefGoogle ScholarPubMed
Harper, A. E. (1959). Amino acid balance and imbalance. 1. Dietary level of protein and amino acid imbalance. Journal of Nutrition 68, 405–418.CrossRefGoogle Scholar
Hurwitz, S. & Bar, A. (1966). Rate of passage of calcium-45 and Yttrium-91 along the intestine, and calcium absorption in the laying fowl. Journal of Nutrition 89, 311–316.CrossRefGoogle ScholarPubMed
Karbach, U. & Feldmeier, H. (1993). The cecum is the site with the highest calcium absorption in rat intestine. Digestive Diseases and Sciences 38, 1815–1824.CrossRefGoogle ScholarPubMed
Kawashima, H. & Kurokawa, K. (1983). Unique hormonal regulation of vitamin D metabolism in the mammalian kidney. Mineral and Electrolyte Metabolism 9, 227–235.Google ScholarPubMed
Kaye, M. & Silverman, M. (1965). Calcium metabolism in chronic renal failure. Journal of Laboratory and Clinical Medicine 66, 535–548.Google ScholarPubMed
Koller, M. & Binswanger, U. (1982). Calcium transport in the ileum of uremic rats. American Journal of Physiology 242, G128–G134.Google ScholarPubMed
Marcus, C. S. & Lengemann, F. W. (1962). Absorption of Ca45 and Sr85 from solid and liquid food at various levels of the alimentary tract of the rat. Journal of Nutrition 77, 155–160.CrossRefGoogle ScholarPubMed
Morrison, A. B. (1962). Experimentally induced chronic renal insufficiency in the rat. Laboratory Investigation 11, 321–332.Google ScholarPubMed
Ohta, A., Baba, S., Ohtsuki, M., Taguchi, A., Adachi, T. & Hara, H. (1996). Prevention of coprophagy modifies magnesium absorption in rats fed with fructo-oligosaccharides. British Journal of Nutrition 75, 775–784.CrossRefGoogle ScholarPubMed
Ohta, A., Ohtuki, M., Takizawa, T., Inaba, H., Adachi, T. & Kimura, S. (1994). Effects of fructooligosaccharides on the absorption of magnesium and calcium by cecectomized rats. International Journal of Vitamin and Nutrition Research 64, 316–323.Google ScholarPubMed
Oku, T., Konishi, F. & Hosoya, N. (1982). Mechanism of inhibitory effect of unavailable carbohydrate on the intestinal calcium absorption. Journal of Nutrition 112, 410–415.CrossRefGoogle ScholarPubMed
Reeves, P. G. (1989). AIN-76 diet: should we change the formulation Journal of Nutrition 119, 1081–1082.CrossRefGoogle ScholarPubMed
Shiffl, H. & Binswanger, U. (1980). Calcium ATPase and intestinal calcium transport in uremic rats. American Journal of Physiology 238, G424–G428.Google Scholar
Statistical Analysis Systems (1989). SAS User's Guide, Statistics. Release 6.0.8. Cary, NC; SAS Institute Inc.Google Scholar
Takahashi, H., Yang, S. I., Kim, M. & Yamamoto, T. (1994 a). Protein and energy utilization of growing rats fed on the diets containing intact or partially hydrolyzed guar gum. Comparative Biochemistry and Physiology 107A, 255–260.Google Scholar
Takahashi, H., Yang, S. I., Ueda, Y., Kim, M. & Yamamoto, T. (1994 b). Influence of intact and partially hydrolyzed guar gum on iron utilization in rats fed on iron-deficient diets. Comparative Biochemistry and Physiology 109, 75–82.CrossRefGoogle Scholar
van der Aar, P. J., Fahey, G. C. Jr, Ricke, S. C., Allen, S. E. & Berger, L. L. (1983). Effects of dietary fibers on mineral status of chicks. Journal of Nutrition 113, 653–661.CrossRefGoogle ScholarPubMed
Walling, M. W., Kimberg, D. V., Wasserman, R. H. & Feinberg, R. R. (1976). Duodenal active transport of calcium and phosphate in vitamin D-deficient rats: effects of nephrectomy Cestrum diurnum, and lα, 25-dihydroxy vitamin D3. Endocrinology 98, 1130–1134.CrossRefGoogle Scholar