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Effects of ascorbic acid on the skeletal response of chicks to vitamin D deficiency*

Published online by Cambridge University Press:  09 March 2007

P. A. Thornton
P. A. Thornton
Affiliation:
Veterans Administration Hospital, Lexington, Kentucky, Departments of Physiology and Biophysics and of Medicine, University of Kentucky, Lexington, Kentucky, USA
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Abstract

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1. The skeletal response of vitamin D-deficient chicks to dietary ascorbic acid was tested.

2. The epiphyseal cartilaginous plate width, which was increased by the vitamin D deficiency, was further increased when ascorbic acid was added and the effect appeared sooner.

3. Absence of vitamin D was associated with a reduction in the relative amount of cancellous to compact bone ash in the tibia. Dietary ascorbic acid intensified this effect to a significant degree.

4. Plasma ascorbic acid levels in rachitic chicks were approximately 25% less than in controls. This observation may explain the skeletal response to added vitamin C and suggests that avian bone tissue has a particularly high requirement for this vitamin.

Type
Research Article
Information
British Journal of Nutrition , Volume 22 , Issue 1 , February 1968 , pp. 77 - 82
Copyright
Copyright © The Nutrition Society 1968

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