Die Konzeption der Heidelberger Ionentherapieanlage HICAT

doi:10.1078/0939-3889-00197

Zeitschrift für Medizinische Physik

Volume 14, Issue 1, 2004, Pages 17-24

https://doi.org/10.1078/0939-3889-00197 Get rights and content

Zusammenfassung

Die zur Zeit im Aufbau befindliche Ionentherapieanlage HICAT an der Universitätsklinik Heidelberg wird die erste klinische Bestrahlungsanlage für Schwerionen in Europa sein. Ihre Kapazität soll die Behandlung von 1000 Patienten pro Jahr ermöglichen. Der Einsatz verschiedener Ionensorten von Protonen bis Sauerstoff unter identischen Bedingungen soll die Frage nach der am besten geeigneten Teilchensorte in Abhängigkeit von der Indikation klären. Ein Synchrotron beschleunigt die Teilchen auf Energien, die wasseräquivalenten Reichweiten von 2 cm bis 30 cm entsprechen. Um die günstige Tiefendosisverteilung von Ionen bestmöglich zu nutzen, wird das intensitätsgesteuerte Rasterscanverfahren eingesetzt. Ein weltweites Novum ist die geplante Schwerionengantry. Die Anlage soll 2006 fertiggestellt sein.

Abstract

The ion beam therapy facility HICAT presently under construction at the Heidelberg University Clinic will be the first clinical irradiation facility for heavy ions in Europe. Its capacity should enable the treatment of 1000 patients per year. The use of different ion species ranging from protons to oxygen under identical conditions should clarify the question of which particle species is best suited in terms of indication. A synchrotron will accelerate the particles to energies corresponding to water-equivalent ranges from 2 cm to 30 cm. An intensity-controlled raster scanning technique will be used to optimize the use of the favorable depth dose distribution of ions. The planned heavy-ion gantry will be the first world-wide. The facility should be complete in 2006.

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Cited by (25)

Radiation tolerance of the rat spinal cord after 6 and 18 fractions of photons and carbon ions: Experimental results and clinical implications
2006, International Journal of Radiation Oncology Biology Physics
Citation Excerpt :
All these facilities use carbon ions for treatment of tumor patients. Encouraging clinical results in patients treated at GSI (10–14) lead to the construction of a hospital-based facility at the University Clinic in Heidelberg, which will deal with all ion types between protons and oxygen (15, 16). Start of clinical operation is scheduled for 2007.
Purpose: The tolerance of the rat spinal cord to photon and carbon ion irradiations was investigated to determine the relative biologic effectiveness (RBE) of carbon ions (¹²C) in the plateau region and in a 1 cm spread-out Bragg-peak.
Methods and Materials: The cranial part of the cervical and thoracic spinal cord of 336 rats was irradiated with 6 or 18 fractions (Fx) of photons or ¹²C-ions, respectively. Animals were followed up for 300 days for the onset of paresis grade II and dose-response curves were calculated.
Results: The D₅₀-values (dose at 50% complication probability) were 42.9 ± 0.5 Gy, 62.2 ± 0.9 Gy (6 and 18 Fx, ¹²C-plateau) and 19.2 ± 0.2 Gy, 17.6 ± 0.2 Gy (6 and 18 Fx ¹²C-peak), respectively. For photons, the D₅₀-values were 57.0 ± 0.7 Gy for 6 and 88.6 ± 0.7 Gy for 18 Fx. The corresponding RBE-values were 1.33 ± 0.02, 1.42 ± 0.02 (6 and 18 Fx, ¹²C-plateau) and 2.97 ± 0.05, 5.04 ± 0.08 (6 and 18 Fx ¹²C-peak), respectively. Including data of a previously performed experiment for 1 and 2 Fx (1) the parameter α/β of the LQ-model was found to be 2.8 ± 0.4 Gy, 2.1 ± 0.4 Gy and 37.0 ± 5.3 Gy for photon-, ¹²C-plateau- and ¹²C-peak irradiations, respectively.
Conclusions: Carbon ion irradiations of the spinal cord are significantly more effective in the peak than in the plateau region. The α/β-values indicate a significant fractionation effect only for the plateau irradiations. In the Bragg-peak, the applied RBE-model correctly describes the main features although it generally underestimates the RBE by 25%. In the plateau region, maximum deviations of up to 20% were found. The acquired data contribute significantly to the validation of the applied RBE-model.
Beam-transport study of an isocentric rotating ion gantry with minimum number of quadrupoles
2005, Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
A beam-transport study of an isocentric gantry for ion therapy is presented. The gantry is designed with the number of quadrupoles down to the theoretical minimum, which is the feature published for the first time in this paper. This feature has been achieved without compromising the ion-optical functions of the beam-transport system that is capable of handling non-symmetric beams (beams with different emittances in vertical and horizontal plane), pencil-beam scanning, double-achromatic optics and beam-size control. Ion-optical properties of the beam-transport system are described, discussed and illustrated by computer simulations performed by the TRANSPORT-code.
Optics design of the extraction lines for the MedAustron hadron therapy centre
2005, Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
The MedAustron hadron therapy centre will provide proton and carbon ion beams for tumour treatment. The accelerator complex is based on a synchrotron that will employ slow resonant extraction to provide beams with the time structure required for active scanning. Four medical treatment rooms and two research rooms are foreseen for the centre. The present paper describes the optics design of the extraction lines that link the synchrotron to the different beam application rooms. A modular approach has been adopted to facilitate running-in and operation and to minimise the number of different magnets and power converters to reduce the overall cost. Specific attention was given to the rather special transverse properties of the slow-extracted beam and to the correct matching of the strongly asymmetric beam to the rotational optics of the gantries. Another important aspect for the design was the overall compactness of the centre.
Comments to the forum of M. Goitein (multiple letters)
2004, Zeitschrift fur Medizinische Physik
Motion in radiotherapy: Particle therapy
2011, Physics in Medicine and Biology
Speed and accuracy of a beam tracking system for treatment of moving targets with scanned ion beams
2009, Physics in Medicine and Biology

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ORIGINALARBEITDie Konzeption der Heidelberger Ionentherapieanlage HICAT

Zusammenfassung

Abstract

Int. J. Radiat. Oncol. Biol. Phys.

NIM

Int. J. Radiat. Oncol. Biol. Phys.

Int. J. Radiat. Oncol. Biol. Phys.

Results of heavy ion radiotherapy

Radiat. Environ. Biophys.

Clinical Progammes: a review of past and existing hadron protocols

Clinical Trial of Heavy-Ion Cancer Treatment at NIRS

STA Today

Bestrahlung von Schädelbasistumoren mit Kohlenstoffionen bei der GSI

Strahlenther. Onkol.

Is there a role for Heavy Ion Beam Therapy?

Recent Results in Cancer Research

HICAT – The German Hospital-Based Light Ion Cancer Therapy Project

PAC

Determination of water absorbed dose in a carbon ion beam using thimble ionization chambers

Phys. Med. Biol.

Selection of beam angles for radiotherapy of skull base tumours using charged particles

Phys. Med. Biol.

ORIGINALARBEIT
Die Konzeption der Heidelberger Ionentherapieanlage HICAT