What determines differentiation of urothelial umbrella cells?
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Keratinocyte Growth Factor Reduces Injury and Leads to Early Recovery from Cyclophosphamide Bladder Injury
2020, American Journal of PathologyCitation Excerpt :From 4 to 24 hours, increased apoptosis of intermediate and possibly basal cells was observed. Although both the apoptotic and nonapoptotic modes of cell death have been reported in many rodent models, few have examined time points earlier than 12 to 24 hours20–22 and none, to our knowledge, has used cell-specific markers to detail the spatiotemporal injury patterns.23–25 One report in rats examined multiple time points within 24 hours after cyclophosphamide infusion and without cell-specific labeling and noted that superficial cells underwent necrotic (nonapoptotic) cell death within 6 hours, followed by waves of apoptosis within deeper layers from 12 to 24 hours, similar to our findings.25
TiO<inf>2</inf> nanostructures in biomedicine
2016, Advances in Biomembranes and Lipid Self-AssemblyCitation Excerpt :Besides that, the majority of the superficially positioned cells grown on all three different nanostructured TiO2 scaffolds and on the porous membrane exhibited microvilli on their apical surface (Fig. 11), indicating that they were at a similar differentiation stage [32]. Some of the cells grown on nanowires (Fig. 11A) and the porous membrane (Fig. 11D) also showed ropy ridges [32], which are typical markers of successive differentiation following microvilli [51–53]. However, some cells grown on nanotubes and nanospheres exhibited unusual ridges, which we named pleomorphic ridges (Fig. 11B and D).
The Golgi complex: An organelle that determines urothelial cell biology in health and disease
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