Molecular & Cellular Proteomics
Regular ArticlesIntegrative Network Analysis Combined with Quantitative Phosphoproteomics Reveals Transforming Growth Factor-beta Receptor type-2 (TGFBR2) as a Novel Regulator of Glioblastoma Stem Cell Properties*
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Author contributions: Y.N., H.K., T.A., and M.O. designed research; Y.N., H.K., and R.K. performed research; K.T., J.I., T.A., and M.O. contributed new reagents or analytic tools; Y.N., H.K., R.K., K.T., J.I., T.A., and M.O. analyzed data; Y.N. and M.O. wrote the paper.
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This work was supported by Research Program of Innovative Cell Biology by Innovative Technology (Integrated Systems Analysis of Cellular Oncogenic Signaling Networks), Grants-in-Aid for Scientific Research on Innovative Areas (Protein Modifications in Pathogenic Dysregulation of Signaling) and Grant-in-Aid for Scientific Research (C).
This article contains supplemental materials.
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The abbreviations used are:
- NSC
neural stem cell
- ACVR
activin receptor
- AKT1
RAC-alpha serine/threonine-protein kinase
- ARHGEF7
Rho guanine nucleotide exchange factor 7
- BAIAP2
brain-specific angiogenesis inhibitor 1-associated protein 2
- bFGF
basal fibroblast growth factor
- BiNGO
Biological Networks Gene Ontology tool
- CXCR4
C-X-C chemokine receptor type 4
- CAMK1
calcium/calmodulin-dependent protein kinase type-1
- DMEM/F12
Dulbecco's modified Eagle's medium: Nutrient Mixture F-12
- EGF
epidermal growth factor
- FASP
filter aided sample preparation
- FDR
false discovery rate
- GFAP
glial fibrillary acidic protein
- GO
gene ontology
- HRP
horseradish peroxidase
- IDH1/2
isocitrate dehydrogenase 1/2
- IPA
Ingenuity Pathway Analysis
- ITGA4
integrin alpha-4
- LC-MS/MS
liquid chromatography-tandem mass spectrometry
- LTQ
Linear Trap Quadropole
- MAPK
mitogen-activated protein kinase
- MYL12A
myosin regulatory light chain 12A
- PKA
protein kinase A
- Rho
Ras homolog gene family
- RNAi
RNA interference
- s.d.
standard deviation
- SILAC
stable isotope labeling by amino acids in cell culture
- TGFBR1/2
transforming growth factor-beta receptor type-1/2.