Journal of Biological Chemistry
MicrobiologyMechanistic insights into avian reovirus p17-modulated suppression of cell cycle CDK–cyclin complexes and enhancement of p53 and cyclin H interaction
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This work was supported by Taichung Veterans General Hospital Grants TCVGH-NCHU1057603 and TCVGH-NCHU1067601, National Chung Hsing University Grants TCVGH-NCHU1057603 and TCVGH-NCHU1067601, Ministry of Science and Technology of Taiwan Grants MOST 106-2313-B-005-054-MY3 and 106-2622-B-005-009-CC2, and the iEGG and Animal Biotechnology Center from the Feature Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan. The authors declare that they have no conflicts of interest with the contents of this article.
This article contains Tables S1–S4 and Figs. S1–S11.
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The abbreviations used are:
- CDK
cyclin-dependent kinase
- ARV
avian reovirus
- CAK
CDK-activating kinase
- IP
immunoprecipitation
- DMEM
Dulbecco's modified Eagle's medium
- FBS
fetal bovine serum
- GST
glutathione S-transferase
- MOI
multiplicity of infection
- p-
phosphorylated
- PMSF
phenylmethylsulfonyl fluoride
- hpi
hours postinfection
- MEM
minimum essential medium.