Journal of Biological Chemistry
Mechanisms of Signal Transductionα-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells*
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The abbreviations used are: α-syn, α-synuclein; CK, casein kinase; DMAT, 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole; DRB, 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole; wt, wild type; siRNA, small interfering RNA; PIPES, 1,4-piperazinediethanesulfonic acid; CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid; PLK, polo-like kinase; PD, Parkinson disease; MSA, Multiple system atrophy; MT, microtubular; DAPI, 4′,6-diamidine-2′-phenylindole dihydrochloride; Dyrk1A, dual-specificity tyrosine phosphorylation-regulated kinase 1A; PS, phosphatidylserine.
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M. K. Mbefo, K. E. Paleologou, A. Boucharaba, A. Oueslati, D. Olschewski, H. Hirling, and H. A. Lashuel. α-Synuclein in Health and Disease, Lausanne, Switzerland, September 24-26, 2008, p. 21 (abstr.).
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Riedel, M., Goldbaum, O., and Richter-Landsberg, C. (2009) J. Mol. Neurosci. in press.
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This work was supported by the Lundbeck Foundation, Danish Research Council for Health and Disease Grant 271-05-0166, the Aarhus University Research Foundation, The Danish Parkinson's Disease Foundation, Wacherhausen Foundation, National Health and Medical Research Council Grant 275528, Nordic Center of Excellence for Neurodegenerative Disorders, the Foundation of 2/7-1984 to Treatment of Parkinson's Disease, and the innovation consortium CureND.
The on-line version of this article (available at http://www.jbc.org) contains supplemental Figs. 1 and 2.