Journal of Biological Chemistry
Volume 292, Issue 18, 5 March 2017, Pages 7688-7705
Editors' PicksThe S1 helix critically regulates the finely tuned gating of Kv11.1 channels
Under a Creative Commons license
open access
biophysics
cardiovascular disease
channel activation
electrophysiology
hERG
ion channel
mutagenesis in vitro
nuclear magnetic resonance (NMR)
oocyte
potassium channel
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This work was supported in whole or part by Australian Research Council Discovery Grant DP150101929 , National Health and Medical Research Council Program Grant App1074386 , and National Health and Medical Research Council Fellowship App1116948 (to J. I. V). The authors declare that they have no conflicts of interest with the contents of this article.
This article was selected as one of our Editors' Picks.
This article contains supplemental Tables S1–S3.
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Both authors should be considered joint first authors.
© 2017 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.