Journal of Biological Chemistry
ImmunologyMitochondria Regulate Neutrophil Activation by Generating ATP for Autocrine Purinergic Signaling*
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This work was supported, in whole or in part, by National Institutes of Health Grants GM-51477, GM-60475, AI-072287, and AI-080582 (to W. G. J.). This work was also supported by Congressionally Directed Medical Research Program PR043034 (to W. G. J.) and Deutsche Forschungsgemeinschaft Grant LE-3209/1-1 (to C. L.) and by support provided through the Harvard Digestive Diseases Center.
This article contains supplemental Figs. 1–4 and Movies S1–S8.
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The abbreviations used are:
- PMN
polymorphonuclear neutrophil
- 2DG
2-deoxy-d-glucose
- CCCP
carbonyl cyanide m-chlorophenylhydrazone
- DHR
dihydrorhodamine
- fMLP
formyl-methionyl-leucyl-phenylalanine
- FPR
formyl peptide receptor
- HBSS
Hanks' balanced salt solution
- iATP
intracellular ATP
- KCN
potassium cyanide
- ROS
reactive oxygen species
- Δψm
mitochondrial membrane potential
- panx1
pannexin-1
- BAPTA-AM
1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester).