Journal of Biological Chemistry
Volume 285, Issue 15, 9 April 2010, Pages 11584-11595
Molecular Bases of DiseaseTerpestacin Inhibits Tumor Angiogenesis by Targeting UQCRB of Mitochondrial Complex III and Suppressing Hypoxia-induced Reactive Oxygen Species Production and Cellular Oxygen Sensing*
Under a Creative Commons license
open access
Drug Action
Hypoxia
Mitochondria
Reactive Oxygen Species (ROS)
Tumor Metastases
Electron Transport Chain
Hypoxia-inducible Factor
Terpestacin
Tumor Angiogenesis
UQCRB of Complex III
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This work was supported by the National R & D Program for Cancer Control, Ministry of Health & Welfare, the Translational Research Center for Protein Function Control, KRF Grant 2009-0083522, the National Research Foundation of Korea Grant funded by Korean Government Grant 2009-0092964, and the Brain Korea 21 project of the Republic of Korea. This work was supported, in whole or in part, by National Institutes of Health Grants HL35440 and HL079650 (to P. T. S. and P. T. M.).
The on-line version of this article (available at http://www.jbc.org) contains supplemental Figs. S1–S5.
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Both authors contributed equally to this work.
© 2010 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.