Molecular & Cellular Proteomics
ResearchInteractome Mapping of the Phosphatidylinositol 3-Kinase-Mammalian Target of Rapamycin Pathway Identifies Deformed Epidermal Autoregulatory Factor-1 as a New Glycogen Synthase Kinase-3 Interactor*
Cited by (0)
- *
This work was supported in part by Association de Recherche sur le Cancer Grant 3853.
This article contains supplemental Figs. 1 and 2, Data 1 and 2, Tables I and II, and materials and methods.
- 1
The abbreviations used are:
- PI3K
phosphatidylinositol 3-kinase
- ABI1
Abelson interactor protein-1
- AD
activation domain
- AKT
protein kinase B
- AMPK
AMP-activated kinase
- APPL1
adaptor protein-containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif
- ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
- BHLHB2/DEC1
basic helix-loop-helix domain-containing, class B, 2
- CK2
casein kinase 2
- CKIP1/PLEKHO1
pleckstrin homology domain-containing, family O member 1
- co-AP
co-affinity purification
- CPE
carboxypeptidase E
- DB
DNA binding domain
- DEAF1/NUDR
deformed epidermal autoregulatory factor-1
- EAAT4
excitatory amino acid transporter 4
- GLUT4
glucose transporter 4
- GSK3
glycogen synthase kinase 3
- HIS3
imidazoleglycerol-phosphate dehydratase
- 5-HT
5-hydroxytryptamine (serotonin)
- 5-HT1A
serotonin receptor 1A
- hVps15
human vacuolar protein sorting 15 or phosphoinositide 3-kinase, class 3, regulatory subunit
- hVps34
human vacuolar protein sorting 34 or phosphoinositide 3-kinase, class 3, catalytic subunit
- IGF1
insulin-like growth factor 1
- IP
immunoprecipitation
- IRS
insulin receptor substrate
- KIF1C
kinesin family member 1C
- lacZ
β-d-galactosidase LacZ
- LZTS2
leucine zipper, putative tumor suppressor 2
- MAPK
mitogen-activated protein kinase
- MO25
calcium-binding protein 39
- MTM1
myotubularin 1
- mTOR
mammalian target of rapamycin, subunit 1
- PDK1
3-phosphoinositide-dependent protein kinase
- PPI
protein-protein interaction
- PRKAA1
5′-AMP-activated protein kinase, catalytic α-1 chain
- RC3H1/Roquin
ring finger and CCCH-type zinc finger domains 1
- RHEB
Ras homolog enriched in brain
- RHEBL1
Ras homolog enriched in brainlike 1
- S6K
ribosomal protein S6 kinase
- SGK1
serum/glucocorticoid-regulated kinase 1
- SHIP
SH2-containing inositol phosphatase
- SPG21/Maspardin
spastic paraplegia 21
- STK11/LKB1
serine/threonine kinase 11
- TNFR1
tumor necrosis factor receptor superfamily, member 1
- TRAF2
tumor necrosis factor receptor-associated factor 2
- TSC
tuberous sclerosis
- URA3
orotidine-5′-phosphate decarboxylase
- Y2H
yeast two-hybrid
- ZBED3
zinc finger, BED domain-containing 3
- PMID
PubMed Unique Identifier
- GFP
green fluorescent protein
- aa
amino acids.
- §
Supported by an Association Française contre les Myopathies grant. Present address: UMR955 Inst. National de la Recherche Agronomique, Ecole Nationale Vétérinaire d'Alfort, 7 ave. du Général de Gaulle, F-94700 Maisons-Alfort, France.
- §§
Both authors contributed equally to this work.