Journal of Biological Chemistry
Volume 285, Issue 49, 3 December 2010, Pages 38270-38282
EnzymologyStructural and Biochemical Characterization of Mycobacterium tuberculosis CYP142: EVIDENCE FOR MULTIPLE CHOLESTEROL 27-HYDROXYLASE ACTIVITIES IN A HUMAN PATHOGEN*
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open access
Cholesterol Metabolism
Crystal Structure
Cytochrome P450
Enzyme Catalysis
Hydroxylase
Azole Drugs
Drug Target
Hemoprotein
Mycobacterium tuberculosis
Redox Potentiometry
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The atomic coordinates and structure factors (code 2XKR) have been deposited in the Protein Data Bank, Research Collaboratory for Structural Bioinformatics, Rutgers University, New Brunswick, NJ (http://www.rcsb.org/).
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This work was supported, in whole or in part, by National Institutes of Health Grant GM062882 (to I. A. P.). This work was also supported by European Union FPVI Project NM4TB.
The on-line version of this article (available at http://www.jbc.org) contains supplemental Figs. S1–S9.
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Royal Society University Research Fellow.
© 2010 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.