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J. Biol. Chem., Vol. 276, Issue 47, 44247-44257, November 23, 2001
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From the Howard Hughes Medical Institute, Vollum Institute, Oregon
Health Sciences University, Portland, Oregon 97201
Guanine nucleotide exchange factors of the
Dbl family relay signals from membrane receptors to Rho family GTPases.
We now demonstrate that a longer transcript of the Lbc gene
encodes a chimeric molecule, which we have called AKAP-Lbc, that
functions as an A-kinase-anchoring protein (AKAP) and a Rho-selective
guanine nucleotide exchange factor. Expression of AKAP-Lbc in
fibroblasts favors the formation of stress fibers in a
Rho-dependent manner. Application of lysophosphatidic acid
or selective expression of G The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF406992.
AKAP-Lbc Anchors Protein Kinase A and
Nucleates G
12-selective Rho-mediated Stress Fiber
Formation*
12 enhances
cellular AKAP-Lbc activation. Furthermore, biochemical studies indicate
that AKAP-Lbc functions as an adaptor protein to selectively couple
G12 to Rho. Thus, AKAP-Lbc anchors PKA and nucleates the
assembly of a Rho-mediated signaling pathway.
*
This work was supported by National Institutes of
Health Grant DK44239 (to J. D. S.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: Howard Hughes Medical
Institute, Vollum Institute, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97201. Tel.: 503-494-4656; Fax:
503-494-0519; E-mail: scott@ohsu.edu.
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