ReportsPhototesting in lupus erythematosus: A 15-year experience☆,☆☆,★
Section snippets
Patients
Photoprovocation tests were performed in 405 white patients (139 men [34%] and 266 women [66%]) with different forms of LE seen at the Department of Dermatology, Heinrich-Heine-University, Düsseldorf, Germany (Table I). The study included 94 patients with discoid LE (DLE); 70 with LET; 81 with subacute CLE (SCLE); 133 with various other forms of CLE, such as LE profundus, hypertrophic/verrucous LE, and chilblain LE; and 27 with SLE. Diagnosis of the forms of CLE was based on clinical and
Erythematous and pigmentary reactions
The MED-UVB in 405 patients with different forms of LE was 99.5 ± 36.1 mJ/cm2, compared with 97.4 ± 39.2 mJ/cm2 in 540 patients in the control group (Table I). For UVA, the IPD threshold dose was 38.8 ± 21.9 J/cm2 and the MTD was 48.8 ± 22.5 J/cm2 in patients with LE compared with 36.4 ± 21.2 J/cm2 and 47.9 ± 22.4 J/cm2, respectively, in the control group. Statistical analysis revealed no significant differences in the time course with respect to the different clinical subtypes of LE or between
Discussion
In 1986, our group8 established standardized methods for testing photosensitive diseases, and, moreover, we showed that the action spectrum of LE included UVA in addition to UVB.9, 17 Further studies by other groups followed, confirming that skin lesions in this disease might also occur after UVA irradiation (Table IV).18, 19, 20, 21, 22, 23, 24
Empty Cell Empty Cell Positive phototest reactions in different subtypes of LE Empty Cell Year Authors Tested
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Cited by (161)
Turn the light on photosensitivity
2021, Journal of Photochemistry and PhotobiologyGuideline for the diagnosis, treatment and long-term management of cutaneous lupus erythematosus
2021, Journal of AutoimmunityA novel humanized cutaneous lupus erythematosus mouse model mediated by IL-21-induced age-associated B cells
2021, Journal of AutoimmunityCitation Excerpt :Extensive research has focused on apoptotic KCs and the immunological molecules involved in the disease. Evidence also confirms that environmental elements, like sunlight, ultraviolet (UV) rays, and biological stressors, are potential triggers in lupus [4–6]. To date, most models of LE focus on SLE, and the animals display a transcriptome that confer SLE susceptibility, thereby performing idiopathic nephritis and anomalous release of autoantibodies, including NZB/W F1 mice [7], MRL/lpr mice [8], BXSB/Yaa mice [9] and the newly developed PD-1H KO mice [10].
Skin
2021, Lahita’s Systemic Lupus ErythematosusCutaneous lupus erythematosus
2020, Systemic Lupus Erythematosus: Basic, Applied and Clinical AspectsSystemic lupus erythematosus: Diagnosis and clinical management
2019, Journal of Autoimmunity
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Supported by a Lise-Meitner scholarship and a research grant of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany (to A. Kuhn).
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Reprint requests: Annegret Kuhn, MD, Institute of Cell Biology, ZMBE, Westfälische Wilhelms-University, Von-Esmarch-Strasse 56, D-48149 Münster, Germany.
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J Am Acad Dermatol 2001;45:86-95