Original articalEpidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in wisconsin: a statewide population-based study☆
Section snippets
Study setting and formation of the wisconsin pediatric inflammatory bowel disease alliance
Identification of new pediatric IBD diagnoses was based on voluntary reporting from pediatric gastroenterology subspecialists. All pediatric gastroenterologists within Wisconsin (n = 17) and those from neighboring states bordering the southern (Illinois, n = 2) and western (Minnesota, n = 2) areas of Wisconsin, who might provide care for resident children, participated in the study. These physicians were based in three academic institutions and five community-based practices within Wisconsin, two
Population characteristics and inflammatory bowel disease incidence
In 2000, Wisconsin had 5.4 million persons, and children <18 years accounted for 26% of the total state population. During the 24-month study period, there were 2.8 million person-years of observation, with 199 incident cases of IBD (129 CD, 60 UC, 10 IC) in the pediatric population (Fig 1). The overall incidence of IBD was calculated as 7.05 (95% CI, 6.1-8.0) per 100,000. The incidence for CD was 4.56 (95% CI, 3.77-5.35), and the incidence for UC was 2.14 (95% CI, 1.6-2.68).
Figure 2 shows the
Discussion
This study reports the incidence of pediatric CD and UC in a large, defined, ethnically diverse North American population. Important observations identified in this evaluation of pediatric IBD across Wisconsin include (1) the highest pediatric IBD incidence reported in the world to date, (2) a twofold predominance in pediatric CD incidence compared with UC, (3) a significantly higher rate of CD diagnosis among boys compared with girls, (4) a low frequency of patients with positive family
Acknowledgements
We thank Promod Yannemsetty and Prasad Kothembaka for technical assistance and database development, Carolyn Raasch for data collection, and Dr. Theodore M. Kotchen for critical review of the manuscript. Finally, we thank Jan Lenz, executive director, Wisconsin Chapter, Crohn's and Colitis Foundation of America, and Nadine Davis, Head, Wisconsin CCFA Youth Initiative, for their support of this project.
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Supported by National Institutes of Health grant (RR016111, S. K.), the National Institutes of Health Clinical Scholars program (K30HL004111, S. K.), and the general clinical research center at the Medical College of Wisconsin and the Medical College of Wisconsin's Digestive Disease Center (S. K., D. G. B.).