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Planta Med 2008; 74(11): 1363-1367
DOI: 10.1055/s-2008-1081306
Pharmacology
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Mutagenicity and Antimutagenicity of Baccharis dracunculifolia Extract in Chromosomal Aberration Assays in Chinese Hamster Ovary Cells

Carla Carolina Munari1 , Flávia Aparecida Resende1 , Jacqueline Morais Alves1 , João Paulo Barreto de Sousa2 , Jairo Kenupp Bastos2 , Denise Crispim Tavares1
  • 1Universidade de Franca, Franca, São Paulo, Brazil
  • 2Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
Further Information

Publication History

Received: April 10, 2008 Revised: May 5, 2008

Accepted: May 20, 2008

Publication Date:
05 August 2008 (online)

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Abstract

Baccharis dracunculifolia De Candole (Asteraceae), a native plant from the Brazilian ”cerrado”, is widely used in folk medicine as an anti-inflammatory agent and for the treatment of gastrointestinal diseases. B. dracunculifolia has been described as the most important plant source of propolis in southeastern Brazil, which is called green propolis due to its color. The aim of the present study was to evaluate the mutagenic and antimutagenic effects of the ethyl acetate extract of B. dracunculifolia leaves (Bd-EAE) on Chinese hamster ovary cells. On one hand, the results showed a significant increase in the frequencies of chromosome aberrations at the highest Bd-EAE concentration tested (100 μg/mL). On the other hand, the lowest Bd-EAE concentration tested (12.5 μ/mL) significantly reduced the chromosome damage induced by the chemotherapeutic agent doxorubicin. The present results indicate that Bd-EAE has the characteristics of a so-called Janus compound, that is, Bd-EAE is mutagenic at higher concentrations, whereas it displays a chemopreventive effect on doxorubicin-induced mutagenicity at lower concentrations. The constituents of B. dracunculifolia responsible for its mutagenic and antimutagenic effects are probably flavonoids and phenylpropanoids, since these compounds can act either as pro-oxidants or as free radical scavengers depending on their concentration.

Key words

Baccharis dracunculifolia De Candole - Asteraceae - mutagenicity - antimutagenicity - CHO cells - Janus

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Prof. Dr. Denise Crispim Tavares

Universidade de Franca

Avenida Dr. Armando Salles de Oliveira 201

14404–600 Franca, São Paulo

Brazil

Phone: +55-16-3711-8871

Fax: +55-16-3711-8878

Email: denisecrispim2001@yahoo.com

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