Synthesis of the Calcimimetic (+)-NPS R-568

I. Fernandez; V. Valdivia; N. Khiar

doi:10.1055/s-2008-1072605

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Synfacts 2008(6): 0553-0553
DOI: 10.1055/s-2008-1072605

Synthesis of Natural Products and Potential Drugs

Synthesis of the Calcimimetic (+)-NPS R-568

Contributor(s): Philip Kocienski
I. Fernandez*, V. Valdivia, N. Khiar*
University of Seville, Spain

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Publication History

Publication Date:
21 May 2008 (online)

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Significance

The target molecule activates the calcium-sensing receptor in the same way as extracellular Ca²⁺ and therefore has potential for the treatment of primary and secondary hyperparathyroidism. The key step in this synthesis is the highly diastereoselective addition of MeMgBr to the 2-propanesulfinimine D.