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Synfacts 2008(6): 0557-0557  
DOI: 10.1055/s-2008-1072600
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Chlorotonil A

Contributor(s): Philip Kocienski, Arndt W. Schmidt
N. Rahn, M. Kalesse*
Leibniz Universität Hannover, Germany
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Publication History

Publication Date:
21 May 2008 (online)

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Significance

The structure of the myxobacterium Sorangium cellulosum metabolite chlorotonil A was assigned in 2008 (K. Gerth, H. Steinmetz, G. Höfle, R. Jansen Angew. Chem. Int. Ed. 2008, 47, 160). The double carbonyl flanked CCl2 motif and promising first biological data render this molecule an interesting synthetic target.