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Neuropediatrics 1990; 21(3): 124-129
DOI: 10.1055/s-2008-1071477
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Cytomegalovirus Encephalopathy in an Infant with Congenital Acquired Immuno-Deficiency Syndrome

L.  Belec1 , J.  Tayot2 , P.  Tron3 , J.  Mikol4 , F.  Scaravilli5 , F.  Gray1
  • 1Département de Pathologie (Neuropathologie) Hôpital Henri Mondor, F-94010 Créteil Cedex, France
  • 2Laboratoire d'Anatomie Pathologique, Hôpital Charles Nicolle, 1 rue de Germont, F-76031 Rouen Cedex, France
  • 3Service de Pédiatrie et Génétique Médicale, Hôpital Charles Nicolle, 1 rue de Germont, F-76031 Rouen Cedex, France
  • 4Service Central d'Anatomie et de Cytologie Pathologiques, Hôpital Lariboisière, F-75010, France
  • 5Department of Neuropathology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Further Information

Publication History

Publication Date:
19 March 2008 (online)

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Abstract

A female infant born pre-term to a HIV seropositive mother presented at birth with seropositivity for HIV and CMV viruria. At five months of age she developed an AIDS-related complex. Six months later she died from rapidly progressive diffuse encephalopathy. Post mortem examination revealed generalized CMV infection. Neuropathological examination showed a nodular encephalitis with occasional cytomegalic cells containing characteristic CMV inclusion bodies. There was no evidence of HIV encephalitis; immunostaining for HIV antigen (gp 41) was negative. Opportunistic infections in infants with congenital AIDS are the exception. To our knowledge, only one case of CMV encephalitis in an infant with congenital AIDS has been reported previously. In that case, as in the present one, a reactivation of a congenital CMV infection is likely.

Abbreviations

Acquired immuno-deficiency syndrome: AIDS
Cytomegalovirus: CMV
Human Immuno-Deficiency Virus: HIV
Central Nervous System: CNS

Key words

Congenital acquired immuno-deficiency syndrome - Cytomegalovirus encephalitis - HIV encephalitis

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