Int J Sports Med 1991; 12(1): 46-51
DOI: 10.1055/s-2007-1024654
© Georg Thieme Verlag Stuttgart · New York

Doping Control of Testosterone and Human Chorionic Gonadotrophin: A Case Study

D. de Boer, E. G. De Jong, J. M. van Rossum, R. A. A. Maes
  • Netherlands Institute for Drugs and Doping Research, University of Utrecht, Vondellaan 14, 3521 GE Utrecht, The Netherlands
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Publication History

Publication Date:
14 March 2008 (online)

Abstract

Doping control for testosterone and human Chorionic Gonadotrophin (hCG) requires special attention as a difference must be made between the endogenous and exogenous origin of both substances. The detection of exogenous testosterone is based on the ratio of testosterone- to epitestosterone-glucuronide (T/E) in urine. The problems with this ratio are discussed. For hCG analysis in urine the utilization of sandwich-type hCG specific assays instead of hCG/hCGß competitive assays is recommended. A case study in which an athlete self-administered testosterone and hCG before a competition is described. The T/E ratio and hCG concentration in urine were followed during this period of self-administration. The results demonstrate the relevance of the T/E ratio and of the selected hCG assay. The ratio of testosterone to human Luteinizing Hormone (T/hLH) in serum also indicated the use of hormones. Although the athlete's urine was negative for exogenous testosterone directly after competition, he would have been found positive for hCG.

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