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Horm Metab Res 1984; 16(1): 37-40
DOI: 10.1055/s-2007-1014688
© Georg Thieme Verlag, Stuttgart · New York

Alteration of Plasma and Erythrocyte Membrane Lipid Components in Hyperthyroid Rats

F. M. Ruggiero, C. Landriscina, G. V. Gnoni, E. Quagliariello
  • Centro di Studio sui Mitocondri e Metabolismo Energetico presso l'Istituto di Chimica Biologica dell'Università di Bari, Bari, Italy
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Publication History

1982

1983

Publication Date:
14 March 2008 (online)

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Summary

Cholesterol and phospholipid have been measured in plasma and erythrocyte membrane of hyperthyroid rats. It has been found that while the former is reduced by about 30% in plasma and increased by the same amount in erythrocyte membranes, on the contrary, the latter increases by 35% in both plasma and red cell membranes. It seems that when serum triiodothyronine increases, a major cholesterol transfer occurs from plasma to erythrocyte. In this way, by the concomitant phospholipid increase, it is possible to avoid an alteration of the cholesterol/phospholipid molar ratio in the red cells, thus preventing their abnormal function in hyperthyroid rats. The proposal is made that an additional reason for the plasma cholesterol decrease in hyperthyroid subjects can be attributable to a net transfer of this compound from plasma to erythrocyte.

Key-Words:

Cholesterol - Phospholipid - Plasma - Erythrocyte Membrane-Rats - Triiodothyronine (T 3 )

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