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Horm Metab Res 1992; 24(11): 508-510
DOI: 10.1055/s-2007-1003376
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© Georg Thieme Verlag, Stuttgart · New York

Protective Effect of Diltiazem Hydrochloride on the Occurrence of Alloxan- or Streptozotocin-Induced Diabetes in Rats

K. Katsumata1 , K. Katsumata2  Jr. , Y. Katsumata3
  • 1Katsumata Hospital, Nagoya
  • 2Chukyo Hospital, Nagoya
  • 3Department of Legal Medicine, Nagoya University School of Medicine, Nagoya, Japan
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Publication History

1991

1992

Publication Date:
14 March 2008 (online)

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Summary

This study demonstrated that 20 mg/kg of the Ca2+ channel blocker, diltiazem hydrochloride, administered by intraperitoneal injection 15 min before 200 mg/kg of alloxan given by the same route to induce diabetes, served to suppress disease onset completely in rats. Even though 48-h fasting promoted the onset of alloxan diabetes, 40 mg/kg of diltiazem hydrochloride completely prevented the occurrence of diabetes induced by intraperitoneal injection of 200 mg/kg of alloxan. Forty mg/kg of the same agent, however, failed to prevent the onset of diabetes induced by the intravenous injection of streptozotocin (50mg/kg). From the fact that Ca2+ channel blockers such as nicardipine, verapamil and bepridil have a similar suppressive effect on the occurrence of alloxan diabetes, one may readily infer that this action is characteristic of Ca2+ channel blockers. Moreover, the results suggest the close connection of Ca2+ in the occurrence of alloxan diabetes in rats.

Key words

Diabetes - Alloxan - Streptozotocin - Ca2+ Channel Blocker - Diltiazem Hydrochloride

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