Synthesis of (-)-Sarain A

N. K. Garg; S. Hiebert; L. E. Overman

doi:10.1055/s-2006-949386

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Synfacts 2006(11): 1089-1089
DOI: 10.1055/s-2006-949386

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Sarain A

Contributor(s): Phlip Kocienski, John Cooksey
N. K. Garg, S. Hiebert, L. E. Overman*
University of California, Irvine, USA

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Publication History

Publication Date:
24 October 2006 (online)

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Significance

(-)-Sarain A is an alkaloid isolated from the Mediterranean sponge Reniera sarai and exhibits antibacterial, insecticidal and antitumor activity. The Overman group reports the first total synthesis of this structurally complex alkaloid.