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Letter
| Planta Med 2005; 71: 273-274
DOI: 10.1055/s-2005-837829 |
© Georg Thieme Verlag KG Stuttgart · New York |
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Cytotoxic and Antifungal Isoprenylated Xanthones and Flavonoids from Cudrania fruticosa |
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| Yong-Hong Wang1, Ai-Jun Hou1, Guo-Fu Zhu2, Dao-Feng Chen1, Han-Dong Sun3 |
1 Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China
2 School of Chinese Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China
3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Academia Sinica, Kunming, P. R. China |
Abstract
A new isoprenylated xanthone, cudrafrutixanthone A, was isolated from the roots of Cudrania fruticosa, together with 18 known compounds. Their structures were elucidated by spectroscopic methods. Most isoprenylated xanthones exhibited cytotoxicity against HCT-116, SMMC-7721, SGC-7901, and BGC-823 cell lines with IC50 values of 1 - 5 μg/mL. Toxyloxanthone C and wighteone showed antifungal activity against Candida albicans with MICs of 25 and 12.5 μg/mL, respectively.
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