Synthesis 2004: 1859-1863   DOI: 10.1055/s-2004-829123
© Georg Thieme Verlag Stuttgart · New York
Domino Primary Alcohol Oxidation-Wittig Reaction: Total Synthesis of ABT-418 and (E)-4-Oxonon-2-enoic Acid
Jyoti Shet, Vidya Desai, Santosh Tilve*
Department of Chemistry, Goa University, Taleigao Plateau, Goa 403 206, India Fax: +91(832)2451184; e-Mail: santoshtilve@yahoo.com;
Received 2 March 2004

Abstract

Domino oxidation of primary alcohols to α,β-unsaturated compounds using the combination of PCC-NaOAc and stabilized Wittig reagent and its application towards total synthesis of ABT-418 and 4-oxonon-2-enoic acid is described.

Keywords

primary alcohols - oxidation - PCC - olefination - domino reaction