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Planta Med 2004; 70(2): 171-173
DOI: 10.1055/s-2004-815496
Letter
© Georg Thieme Verlag Stuttgart · New York

Anti-Angiogenic Activity of a Homoisoflavanone from cremastra appendiculata

Joong Sup Shim1 , Jin Hee Kim1 , Jiyong Lee1 , Si Na Kim1 , Ho Jeong Kwon1
  • 1Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, Kwangjin-gu, Seoul, Korea
This study was supported by a grant of the Ministry of Health & Welfare, Republic of Korea (HMP-99-D-01-0004) and the Brain Korea 21 project
Further Information

Publication History

Received: July 7, 2003

Accepted: October 18, 2003

Publication Date:
02 March 2004 (online)

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Abstract

A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one (1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

References

  • 1 Adinolfi M, Corsaro M, Lanzetta R, Laonigro G, Mangoni L, Parrilli M. Ten homoisoflavanones from two Muscari species.  Phytochemistry. 1987;  26 285-90
    PubMedGoogle Scholar
  • 2 Crouch N R, Bangani V, Mulholland D A. Homoisoflavanones from three South African Scilla species.  Phytochemistry. 1999;  51 943-6
    CrossrefPubMedGoogle Scholar
  • 3 Vailhé B, Vittet D, Feige J J. In vitro models of vasculogenesis and angiogenesis.  Laboratory Investigation. 2001;  81 439-52
    PubMedGoogle Scholar
  • 4 Kini A R, Peterson L C, Tallman M S, Lingen M W. Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid.  Blood. 2001;  97 3919-24
    CrossrefPubMedGoogle Scholar
  • 5 Shim J S, Kim D H, Jung H J, Kim J H, Lim D, Lee S K, Kim K W, Ahn J W, Yoo J S, Rho J R, Shin J, Kwon H J. Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation.  Bioorganic & Medicinal Chemistry. 2002;  10 2987-92
    CrossrefPubMedGoogle Scholar
  • 6 Sarkar F H, Li Y. Mechanisms of cancer chemoprevention by soy isoflavone genistein.  Cancer Metastasis Review. 2002;  21 265-80
    PubMedGoogle Scholar
  • 7 Tan W F, Lin L P, Li M H, Zhang Y X, Tong Y G, Xiao D, Ding J. Quercetin, a dietary-derived flavonoid, possesses antiangiogenic potential.  European Journal of Pharmacology. 2003;  459 255-62
    CrossrefPubMedGoogle Scholar

Prof. Ho Jeong Kwon

Department of Bioscience and Biotechnology

Institute of Bioscience

Sejong University

98 Kunja-dong

Kwangjin-gu

Seoul 143-747

Korea

Phone: +82-2-3408-3640

Fax: +82-2-3408-3334

Email: kwonhj@sejong.ac.kr

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