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Planta Med 2004; 70(2): 93-103
DOI: 10.1055/s-2004-815483
Review
© Georg Thieme Verlag Stuttgart · New York

Anti-Inflammatory Compounds of Plant Origin. Part II. Modulation of Pro-Inflammatory Cytokines, Chemokines and Adhesion Molecules

João B. Calixto1 , Maria M. Campos1 , Michel F. Otuki1 , Adair R. S. Santos2
  • 1Department of Pharmacology, CCB, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil
  • 2Department of Physiologic Sciences, CCB, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil
Part 1: Planta Med 2003;69:973 - 983Michel F. Otuki is a PhD student in Pharmacology and he thanks CNPq for scholarship support. Maria M. Campos holds a post-doctoral fellowship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). The studies from our group were supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Financiadora de Estudos e Projetos (FINEP) and by Programa de Apoio aos Grupos de Excelência (PRONEX), Brazil
Further Information

Publication History

Received: August 18, 2003

Accepted: October 18, 2003

Publication Date:
02 March 2004 (online)

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Abstract

It has been widely shown that many plant-derived compounds present significant anti-inflammatory effects. For this reason, they represent potential molecules for the development of new drugs, especially designed for the treatment and/or control of chronic inflammatory states such as rheumatism, asthma, inflammatory bowel diseases, atherosclerosis, etc. This review focuses on the naturally-occurring compounds with anti-inflammatory properties and attempts to correlate their actions with the modulation of cytokines and associated intracellular signalling pathways; it continues the review published in the November, 2003 issue of Planta Medica.

Abbreviations

AP-1:activator protein-1

CCR1:chemokine receptor 1

CINC-1:cytokine-induced neutrophil chemoattractant 1

COX:cyclooxygenase

EGCG:(-)-epigallocatechin gallate

ELAM-1:endothelial-leukocyte adhesion molecule-1

ERK:extracellular signal-regulated kinase

GRO:growth-related oncogene

HUVEC:human umbilical vein endothelial cells

ICAM-1:intercellular adhesion molecule-1

IFN:interferon

IL:interleukin

iNOS:inducible nitric oxide synthase

IRA:the natural interleukin receptor activation

JAK:janus kinase

JNK:c-Jun NH2-terminal kinase

LPS:lipopolysaccharide

MAPK:mitogen-activated protein kinases

MCP:monocyte chemotactic protein

MHC:major histocompatibility complex

MIP:macrophage inflammatory protein

MMP:matrix metalloproteinases

MPO:myeloperoxidase

NF-κBnuclear factor kappa B

NO:nitric oxide

PAF:platelet aggregation factor

PGEE:prostaglandin

PK:protein kinase

PMA/TPA:phorbol myristate acetate

RANTES:regulated upon activation normal T-cell expressed and secreted

TGF-β:transforming growth factor-β

TNFα:tumour necrosis factor

VCAM-1:vascular cell adhesion molecule-1

Key words

Medicinal plants - plant constituents - inflammation - cytokines - chemokines - adhesion molecules

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João B. Calixto

Department of Pharmacology

UFSC

Rua Ferreira Lima 82

88015-420, Florianópolis, SC

Brazil

Phone: +55-48-3319491

Fax: +55-48-2224164

Email: calixto@farmaco.ufsc.br

Email: calixto3@terra.com.br

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