Iridoid Glucosides from the Flowers of Barleria lupulina

 

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Abstract

A new iridoid diglucoside, lupulinoside, and eight known iridoid glucosides, acetylbarlerin, ipolamiidoside (3), 6-O-acetylshanzhiside methyl ester, barlerin, shanzhiside methyl ester, mussaenosidic acid, 8-O-acetylshanzhiside, and shanzhiside have been isolated from the flowers of Barleria lupulina. The structure of the new compound was established as 8-O-acetyl-2′-O-(β-glucopyranosyl)mussaenoside by spectroscopic, especially 2D NMR, techniques. When tested for anti-herpes simplex type 1 activity, only compound 3 exhibited antiviral properties. None of the compounds showed cytotoxic effects to the vero cells and none of them inhibited cyclooxygenase-2 enzyme.

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Assoc. Prof. Dr. Apichart Suksamrarn

Department of Chemistry

Faculty of Science

Ramkhamhaeng University

Bangkok 10240

Thailand

Fax: +662-02-3108381

Email: apichart@ram1.ru.ac.th.