A Practical Synthesis of Diethyl 1-Methylthio-2-oxo-2-phenylethylphos­phonates from Diethyl Methylthiomethylphosphonate

 

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Abstract

An efficient synthesis of 2′- and 3′-substituted diethyl 1-methylthio-2-oxo-2-phenylethylphosphonates 3a-k from 2′- and 3′-substituted benzoyl chlorides 2a-k using diethyl methylthio-1-lithiomethylphosphonate is described.

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These reactions are in progress in our laboratory.