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Dtsch Med Wochenschr 2003; 128(9): 447-452
DOI: 10.1055/s-2003-37546
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© Georg Thieme Verlag Stuttgart · New York

Bedeutung des melanokortinergen Systems für die Gewichtsregulation[1]

Relevance of the melanocortinergic system for body weight regulationM. Raab1 , A. Hinney1 , W. Grassl1 , H. Remschmidt1 , J. Hebebrand1
  • 1Klinische Forschergruppe, Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters der Philipps-Universität Marburg (Leiter: Prof. Helmut Remschmidt)
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Publication History

eingereicht: 15.7.2002

akzeptiert: 6.12.2002

Publication Date:
28 February 2003 (online)

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Die Hoffnung, mit Leptin ein potentes Medikament gegen die weit verbreitete „normale“ Adipositas zur Verfügung zu haben, hat sich nicht bestätigt ([39]). Die pharmakologischen Bemühungen konzentrieren sich daher auf nachgeschaltete Regelkreise; insbesondere rückt in jüngster Zeit das melanokortinerge System als neurohumorales Regelwerk des Energiehaushaltes in das Interesse der Forschung. Eine zentrale Stellung kommt dem Melanokortin-4-Rezeptor (MC4R) zu als vielversprechender Zielstruktur für die Einflussnahme auf das Körpergewicht.

1 Die Arbeit wurde unterstützt vom Bundesministerium für Bildung und Forschung (Deutsches Humangenomprojekt: 01 KW 0006 und Nationales Genomforschungsnetz: 01 GS 0118) und von der Deutschen Forschungsgemeinschaft (Re 471/11-2)

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1 Die Arbeit wurde unterstützt vom Bundesministerium für Bildung und Forschung (Deutsches Humangenomprojekt: 01 KW 0006 und Nationales Genomforschungsnetz: 01 GS 0118) und von der Deutschen Forschungsgemeinschaft (Re 471/11-2)

Prof. Dr. Johannes Hebebrand

Klinische Forschergruppe, Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters der Philipps-Universität

Schützenstraße 49

35039 Marburg

Email: hebebran@post.med.uni-marburg.de

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