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Planta Med 2002; 68(8): 719-722
DOI: 10.1055/s-2002-33804
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Saccopetrins A and B, Two Novel γ-Lactones from Saccopetalum prolificum

Ming-Lei Wang1 , Jiang Du1 , Pei-Cheng Zhang1 , Ruo-Yun Chen1 , Fei-Zhi Xie1 , Bin Zhao1 , De-Quan Yu1
  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s of Republic of China
Further Information

Publication History

Received: October 2, 2001

Accepted: March 17, 2002

Publication Date:
09 September 2002 (online)

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Abstract

Two new γ-lactones, saccopetrin A (1) and saccopetrin B (2), together with 10 known compounds have been isolated from the roots of Saccopetalum prolificum. Their structures were established by spectroscopic and chemical methods. The absolute configuration of 1 was determined by chemical transformation and the Mosher method. Cytotoxic activities were evaluated against several different cell lines. Compound 2 exhibited stronger cytotoxic activities than 1 against KB and HCT-8 cell lines at a concentration of 10-5 mol/L.

Key words

Annonaceae - Saccopetalum prolificum - acetogenin-γ-lactones - saccopetrin A - saccopetrin B

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Prof. De-Quan Yu

Institute of Materia Medica

Chinese Academy of Medical Sciences


Peking Union Medical College

Beijing, 100050

People’s Republic of China

Email: dqyu@imm.ac.cn

Fax: +86-10-63017757

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