Download PDF
Synlett 2001; 2001(12): 1889-1892
DOI: 10.1055/s-2001-18770
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Titanium 3,3′-Modified-Biphenolate Complexes Atropisomerically Controlled by TADDOLs: Novel Chiral Lewis Acid Catalysts for Asymmetric Methylation with an Achiral Methyl-Titanium Reagent

Makoto Ueki* , Yosuke Matsumoto, Jonathan J. Jodry, Koichi Mikami
  • * Department of Applied Chemistry, Tokyo Institute of Technology O-okayama, Meguro-ku, Tokyo 152-8552, Japan; Fax: + 81(3)57342776; E-mail: kmikami@o.cc.titech.ac.jp
Further Information

Publication History

Publication Date:
04 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

Chiral Ti complexes, which are constituted of 3,3′-modified-biphenolate (BIPOLate) ligands atropisomerically controlled by (R)-TADDOLs, are shown to be novel chiral Lewis acid catalysts for the methylation reaction of aldehydes with an achiral methyl-titanium reagent. Thus, the chiral 3,3′-modified BIPOLate/TADDOLate-Ti complexes give enhanced enantioselectivities up to 100% enantiomeric excess.

asymmetric methylation - atropisomer - chiral Lewis acid catalyst - chiral titanium complex - 3,3’-modified biphenols

      >