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Planta Med 1999; 65(1): 064-067
DOI: 10.1055/s-1999-13965
Original Paper

Georg Thieme Verlag Stuttgart · New York

Mono- and Sesquiterpenes and Antifungal Constituents from Artemisia Species

R. X. Tan1 , H. Lu2 , J.-L. Wolfender1 , T. T. Yu1,4 , W. F. Zheng1,3 , L. Yang4 , S. Gafner2 , K. Hostettmann2
  • 1Institute of Biotechnology, Department of Biological Science & Technology, Nanjing University, Nanjing, People's Republic of China
  • 2Institute of Pharmacognosy & Phytochemistry, School of Pharmacy, University of Lausanne, Lausanne-Dorigny, Switzerland
  • 3State Key Laboratory for New Drug Research at Shanghai Institute of Materia Medica, Academia Sinica, Shanghai, People's Republic of China
  • 4State Key Laboratory for Applied Organic Chemisty at Lanzhou University, Lanzhou, People's Republic of China
Further Information

Publication History

March 23, 1998

July 26, 1998

Publication Date:
31 December 1999 (online)

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Abstract:

In addition to β-sitosterol and α-amyrin detected in all the investigated species, the extract of the aerial parts of Artemisia giraldii var. giraldii gave stigmasterol, daucosterol, sesamine, luteolin, eupafolin, hispidulin, eupatilin, belamcanidin, pinitol, artemin, ridentin, and a new antifungal monoterpene (named santolinylol) while that of the aerial parts of A. mongolica afforded sesamine, eupafolin, eupatilin, matricarin, and a new germacranolide (3-oxo-11αH-germacra-1(10)E,4 Z-dien-12,6α-olide), and that of the aerial parts of A. vestita yielded stigmasterol, daucosterol, umbelliferone, scopolin, scoparone, and isoscopoletin-O-glucoside. Pinitol, first reisolated from Artemisia genus, was shown to inhibit the growth of the human pathogenic fungi Candida albicans, Aspergillus flavus, A. niger, Geotrichun candidum, Trichophyton rubrum, and Epidermophyton floccosum . Umbelliferone was also active against Candida tropicalis , A. flavus, G. candidum , T. rubrum, and E. floccosum. The flavones hispidulin and belamcanidin were almost equally inhibitory to the growth of A. flavus, G. candidum, T. rubrum , and E. floccosum, and santolinylol to C. albicans, A. flavus , A. niger, G. candidum , T. rubrum, and E. floccosum. In addition, ridentin was active against the growth of the plant pathogenic fungus Cladosporium cucumerinum .

Key words:

Artemisia giraldii var. giraldii - A. mongolica - A. vestita - Compositae - antifungal - sterols - coumarins - flavones - monoterpenes - sesquiterpenes - germacranolides - eudesmanolide - guaianolide - santolinylol - 3-oxo-11αH-germacra-1(10) E,4Z-diene-12,6α-olide

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