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Synlett 1995; 1995(11): 1115-1116
DOI: 10.1055/s-1995-5220
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Aryl- and Heteroaryl-Alkyne Coupling Reactions Catalyzed by Palladium on Carbon and CuI in an Aqueous Medium

Leo Bleicher, Nicholas D. P. Cosford*
  • *SIBIA, 505 Coast Boulevard South, Suite 300, La Jolla, CA 92037, Internet Cosford@SC2.salk.edu
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Publication Date:
31 December 2000 (online)

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A protocol for the efficient coupling of alkynes with aryl and heteroaryl substrates with a Pd/C-CuI-PPh3 catalyst system in aqueous media has been developed. These conditions are tolerant of a variety of unprotected functional groups. Reactions which demonstrate the generality and scope of this methodology are reported.

alkynylation - palladium - cross-coupling - aqueous medium - multi-kilo scale

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